(3R,4S)-3-Hydroxy-4-(tert-butoxycarbonylamino)-5-phenylvaleric acid ethyl ester

Base Information

Chemical Name:(3R,4S)-3-Hydroxy-4-(tert-butoxycarbonylamino)-5-phenylvaleric acid ethyl ester
CAS No.:72155-47-6
Molecular Formula:C₁₈H₂₇NO₅
Molecular Weight:337.416
Hs Code.:
DSSTox Substance ID:DTXSID901122937
Nikkaji Number:J733.401J

Synonyms:Boc-gF(b-OH)-OEt;DTXSID901122937;(3R,4S)-ethyl 4-((tert-butoxycarbonyl)amino)-3-hydroxy-5-phenylpentanoate;(3R,4S)-3-Hydroxy-4-(tert-butoxycarbonylamino)-5-phenylvaleric acid ethyl ester;Ethyl 2,4,5-trideoxy-4-[[(1,1-dimethylethoxy)carbonyl]amino]-5-phenyl-L-erythro-pentonate;72155-47-6

Suppliers and Price of (3R,4S)-3-Hydroxy-4-(tert-butoxycarbonylamino)-5-phenylvaleric acid ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R,4S)-3-Hydroxy-4-(tert-butoxycarbonylamino)-5-phenylvaleric acid ethyl ester

Chemical Property:

XLogP3:2.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:10
Exact Mass:337.18892296
Heavy Atom Count:24
Complexity:399

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC(=O)CC(C(CC1=CC=CC=C1)NC(=O)OC(C)(C)C)O
Isomeric SMILES:CCOC(=O)C[C@H]([C@H](CC1=CC=CC=C1)NC(=O)OC(C)(C)C)O

Technology Process of (3R,4S)-3-Hydroxy-4-(tert-butoxycarbonylamino)-5-phenylvaleric acid ethyl ester

There total 17 articles about (3R,4S)-3-Hydroxy-4-(tert-butoxycarbonylamino)-5-phenylvaleric acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 112271-08-6
(4S)-40<(tertibutyloxycarbonyl)amino>-3-oxo-5-phenylpentanoic acid ethyl ester

: 72155-46-5
(3S,4S)-4-(N-tert-butoxycarbonyl)amino-3-hydroxy-5-phenylpentanoic acid ethyl ester

: 72155-47-6
N-(tert-butoxycarbonyl)-4(S)-amino-3(R)-hydroxy-5-phenylpentanoic acid ethyl ester

Guidance literature:: With hydrogen; (S)-BinapRuBr₂; In ethanol; at 18 - 21 ℃; for 145h; under 76000.1 Torr; Yields of byproduct given; threo/erythro ratio 9/91, ee = 99percent;
DOI:10.1016/S0040-4039(00)82338-2