112271-08-6

Basic information

• Product Name: (4S)-40<(tertibutyloxycarbonyl)amino>-3-oxo-5-phenylpentanoic acid ethyl ester
• Synonyms: (4S)-40<(tertibutyloxycarbonyl)amino>-3-oxo-5-phenylpentanoic acid ethyl ester
• CAS NO: 112271-08-6
• Molecular Weight: 335.4
• Mol File: 112271-08-6.mol
• Article Data: 20

Chemical Properties

• Melting Point: 67.0-68.0 °C
• Boiling Point: 456.7±40.0 °C(Predicted)
• Density: 1.115±0.06 g/cm3(Predicted)
• CAS DataBase Reference: (4S)-40<(tertibutyloxycarbonyl)amino>-3-oxo-5-phenylpentanoic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (4S)-40<(tertibutyloxycarbonyl)amino>-3-oxo-5-phenylpentanoic acid ethyl ester(112271-08-6)
• EPA Substance Registry System: (4S)-40<(tertibutyloxycarbonyl)amino>-3-oxo-5-phenylpentanoic acid ethyl ester(112271-08-6)

Safety Data

• Hazardous Substances Data: 112271-08-6(Hazardous Substances Data)

Usage

General Description

The chemical compound (4S)-40<(tertibutyloxycarbonyl)amino>-3-oxo-5-phenylpentanoic acid ethyl ester is a derivative of a naturally occurring amino acid. It is a specific enantiomer of a compound with a carboxylic acid functional group and a reactive ester group. The presence of a phenyl group in the molecule adds aromatic character to the compound. The tert-butyl group provides steric hindrance around the amino group, which can affect the reactivity and stability of the compound. This chemical may have applications in organic synthesis, medicinal chemistry, or materials science due to its unique structure and reactivity. Additionally, it may serve as a building block for the synthesis of more complex molecules.

Upstream product

• 18942-49-9 Boc-D-Phe-OH 
• 1247065-61-7 C₁₇H₂₁N₃O₃ 
• 141-78-6 ethyl acetate 
• 1071-46-1 hydrogen ethyl malonate 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 87694-53-9 Boc-Phe-OH N,O-dimethyl hydroxamate 
• 66605-57-0 (S)-N-tert-butoxycarbonyl-2-amino-3-phenylpropanol 
• 623-73-4 diazoacetic acid ethyl ester 
• 72155-45-4 Boc-L-phenylalaninal 
• 142955-51-9 N-butoxycarbonyl-L-phenylalanine anhydride 
• 26954-26-7 ethyl lithioacetate 
• 105-36-2 ethyl bromoacetate 
• 168774-14-9 (S)-1-(2'-t-butoxycarbonylamino-3'-phenylpropanoyl)-3,5-dimethylpyrazole 
• 118812-47-8 [(S)-1-Benzyl-2-(4-methyl-3,5-dioxo-[1,2,4]oxadiazolidin-2-yl)-2-oxo-ethyl]-carbamic acid tert-butyl ester 

Downstream Products

• 109667-69-8 (1'R,2'R)-N-<2,4-dihydroxy-4-oxo-1-(phenylmethyl)butyl>carbamic acid 1,1-dimethylethyl ester 
• 1271777-26-4 C₃₃H₄₈N₄O₇ 
• 1271777-32-2 C₂₃H₃₂N₄O₃ 
• 1345837-40-2 (S)-tert-butyl 1-(7-methoxy-2-oxo-2H-chromen-4-yl)-2-phenylethylcarbamate 
• 684643-49-0 H-(SS)-AHPPA-OEt 
• 120742-17-8 ethyl (3S,4S)-3-hydroxy-4-amino-5-phenylpentanoate hydrochloride 
• 1025722-65-9 ethyl (4S,2Z)-4-[N-(tert-butoxycarbonyl)amino]-5-phenyl-3-[(trifluoromethanesulfonyl)oxy]pent-2-enoate 
• 1025723-03-8 ethyl (4S,2E)-4-[N-(tert-butoxycarbonyl)amino]-5-phenyl-3-[(trifluoromethanesulfonyl)oxy]pent-2-enoate 
• 116326-39-7 ES-6864 
• 119379-17-8 (3S,4S)-4-amino-5-cyclohexyl-3-hydroxy-N-(2-morpholinoethyl)pentanamide 
• 119357-93-6 (3S,4S)-4-((S)-2-Amino-3-thiazol-4-yl-propionylamino)-5-cyclohexyl-3-hydroxy-pentanoic acid (2-morpholin-4-yl-ethyl)-amide 
• 124278-64-4 (3S,4S)-4-(N-tert-butoxycarbonyl)amino-5-cyclohexyl-3-hydroxy-N-(2-morpholinoethyl)pentanamide 

Relevant articles and documents

Solid-Phase Synthesis of β-Lactams via the Miller Hydroxamate Approach

(Matrix Presented) β-Lactams were prepared on solid phase starting from serine, threonine, or other β-hydroxyacids derived from naturally occurring amino acids and a resin bound hydroxylamine. The ring closure was carried out under Mitsunobu conditions. The amino group present on the β-lactam was used to assemble a short peptide. After a reductive cleavage with Sml2, β-lactam-containing peptides were obtained.

Helices with additional H-bonds: crystallographic conformations of α,γ-hybrid peptides helices composed of β-hydroxy γ-amino acids (statines)

β-Hydroxy-γ-amino acids (Statines) are a class of naturally occurring non-ribosomal amino acids frequently found in many peptide natural products. Peptidomimetics constituted with statines have been used as inhibitors for various aspartic acid proteases. In contrast to the synthetic γ-amino acids, very little is known about the folding behavior of these naturally occurring β-hydroxy γ-amino acids. To understand the folding behavior of statines, three α,γ-hybrid peptides P1 (Ac-Aib-γPhe-Aib-(R, S)Phesta-Aib-γPhe-Aib-CONH2), P2 (Ac-Aib-γPhe-Aib-(S, S)Phesta-Aib-γPhe-Aib-CONH2), and P3 (Ac-Aib-γPhe-Aib-(S, S)Phesta-Aib-(S, S)Phesta-Aib-CONH2) were synthesized on solid phase and their helical conformations in single crystals were studied. Results suggest that both syn and anti diastereoisomers of statines can be accommodated into the helix without deviating overall helical conformation of α,γ-hybrid peptides. In comparison with syn diastereoisomer, the anti diastereoisomer was found to be directly involved in the intramolecular H-bonding with the backbone carbonyl groups (i to i + 3) similar to the backbone amide NHs in the helix.

Synthesis of tetrasubstituted symmetrical pyrazines from β-keto γ-amino esters: A mild strategy for self-dimerization of peptides

A facile synthesis of highly symmetrical tetrasubstituted pyrazines through simple aerial oxidation of β-keto γ-amino esters is reported. The scope of the reaction was examined by use of various amino acid side-chain functional groups andpeptides. The mil

NOVEL MULTIFUNCTIONAL PEPTIDASE INHIBITORS, ESPECIALLY FOR MEDICAL USE

The invention relates to compounds of the general formula (1) or the acid addition salts thereof with organic and/or inorganic acids; as well as to the use of the compounds of the general formula (1) in medicine.