4,4-difluoro-1,3,5,7-tetramethyl-8-(2-hydroxyphenyl)-4-bora-3a,4a-diaza-s-indacene

Base Information

Chemical Name:4,4-difluoro-1,3,5,7-tetramethyl-8-(2-hydroxyphenyl)-4-bora-3a,4a-diaza-s-indacene
CAS No.:1310926-82-9
Molecular Formula:C₁₉H₁₉BF₂N₂O
Molecular Weight:340.18
Hs Code.:

Synonyms:4,4-difluoro-1,3,5,7-tetramethyl-8-(2-hydroxyphenyl)-4-bora-3a,4a-diaza-s-indacene

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Chemical Property of 4,4-difluoro-1,3,5,7-tetramethyl-8-(2-hydroxyphenyl)-4-bora-3a,4a-diaza-s-indacene

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Technology Process of 4,4-difluoro-1,3,5,7-tetramethyl-8-(2-hydroxyphenyl)-4-bora-3a,4a-diaza-s-indacene

There total 13 articles about 4,4-difluoro-1,3,5,7-tetramethyl-8-(2-hydroxyphenyl)-4-bora-3a,4a-diaza-s-indacene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1384575-38-5
(C₆H₅CH₂OC₆H₄C(C₄HN(CH₃)2)2)BF₂

: 1310926-82-9
4,4-difluoro-1,3,5,7-tetramethyl-8-(2-hydroxyphenyl)-4-bora-3a,4a-diaza-s-indacene

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; at 20 ℃; for 17h;
DOI:10.1021/ja212125w

Reference yield: 35.0%

: 625-82-1
2,4-dimethyl-1H-pyrrole

: 109-63-7
trifluoroborane diethyl ether

: 90-02-8
salicylaldehyde

: 1310926-82-9
4,4-difluoro-1,3,5,7-tetramethyl-8-(2-hydroxyphenyl)-4-bora-3a,4a-diaza-s-indacene

Guidance literature:: With trifluoroacetic acid; tetrachlorobenzoquinone; triethylamine; In dichloromethane; a few drops of CF3COOH were added to a soln. of 2-hydrobenzaldehyde and pyrrole in CH2Cl2, stirred at room temp. for 10 h, Cl4C6O2 in CH2Cl2 wasadded, stirred for 4 h, N(C2H5)3, B-compound were added dropwise, coole d in ice-bath, 2 h stirring; the solvent was removed under reduced pressure, the residue was dissolved in CH2Cl2, the organic layer was washed with water, dried over Na2SO4,the solvent was removed under reduced pressure, column chromy. on silic a gel, ethyl acetate/petroleum ether;
DOI:10.1039/c0ob00910e

Reference yield: 25.0%

: 625-82-1
2,4-dimethyl-1H-pyrrole

: 109-63-7
boron trifluoride diethyl etherate

: 90-02-8
salicylaldehyde

: 1310926-82-9
4,4-difluoro-1,3,5,7-tetramethyl-8-(2-hydroxyphenyl)-4-bora-3a,4a-diaza-s-indacene

Guidance literature:: 2,4-dimethyl-1H-pyrrole; salicylaldehyde; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 24h; Inert atmosphere;

With chloranil; triethylamine; In dichloromethane; at 20 ℃; for 2.5h; Inert atmosphere;

boron trifluoride diethyl etherate; In dichloromethane; at 20 ℃; for 0.5h; Inert atmosphere;
DOI:10.1002/chem.201405450