(R)-(1-(3-(4-(N-(4-(4-(3-(2-(4-chlorophenyl)-1-isopropyl-5-methyl-4-(methylsulfonyl)-1H-pyrrol-3-yl)-5-fluorophenyl)piperazin-1-yl)phenyl) sulfamoyl)-2(trifluoromethylsulfonyl)phenylamino)-4-(phenylthio)butyl)piperidin-4-yloxy)methyl dihydrogen phosphate

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Chemical Name:(R)-(1-(3-(4-(N-(4-(4-(3-(2-(4-chlorophenyl)-1-isopropyl-5-methyl-4-(methylsulfonyl)-1H-pyrrol-3-yl)-5-fluorophenyl)piperazin-1-yl)phenyl) sulfamoyl)-2(trifluoromethylsulfonyl)phenylamino)-4-(phenylthio)butyl)piperidin-4-yloxy)methyl dihydrogen phosphate
CAS No.:1619923-27-1
Molecular Formula:C₅₄H₆₂ClF₄N₆O₁₁PS₄
Molecular Weight:1241.8
Hs Code.:

(R)-(1-(3-(4-(N-(4-(4-(3-(2-(4-chlorophenyl)-1-isopropyl-5-methyl-4-(methylsulfonyl)-1H-pyrrol-3-yl)-5-fluorophenyl)piperazin-1-yl)phenyl) sulfamoyl)-2(trifluoromethylsulfonyl)phenylamino)-4-(phenylthio)butyl)piperidin-4-yloxy)methyl dihydrogen phosphate

Synonyms:(R)-(1-(3-(4-(N-(4-(4-(3-(2-(4-chlorophenyl)-1-isopropyl-5-methyl-4-(methylsulfonyl)-1H-pyrrol-3-yl)-5-fluorophenyl)piperazin-1-yl)phenyl) sulfamoyl)-2(trifluoromethylsulfonyl)phenylamino)-4-(phenylthio)butyl)piperidin-4-yloxy)methyl dihydrogen phosphate

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Chemical Property of (R)-(1-(3-(4-(N-(4-(4-(3-(2-(4-chlorophenyl)-1-isopropyl-5-methyl-4-(methylsulfonyl)-1H-pyrrol-3-yl)-5-fluorophenyl)piperazin-1-yl)phenyl) sulfamoyl)-2(trifluoromethylsulfonyl)phenylamino)-4-(phenylthio)butyl)piperidin-4-yloxy)methyl dihydrogen phosphate

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Technology Process of (R)-(1-(3-(4-(N-(4-(4-(3-(2-(4-chlorophenyl)-1-isopropyl-5-methyl-4-(methylsulfonyl)-1H-pyrrol-3-yl)-5-fluorophenyl)piperazin-1-yl)phenyl) sulfamoyl)-2(trifluoromethylsulfonyl)phenylamino)-4-(phenylthio)butyl)piperidin-4-yloxy)methyl dihydrogen phosphate

There total 3 articles about (R)-(1-(3-(4-(N-(4-(4-(3-(2-(4-chlorophenyl)-1-isopropyl-5-methyl-4-(methylsulfonyl)-1H-pyrrol-3-yl)-5-fluorophenyl)piperazin-1-yl)phenyl) sulfamoyl)-2(trifluoromethylsulfonyl)phenylamino)-4-(phenylthio)butyl)piperidin-4-yloxy)methyl dihydrogen phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1619923-53-3
N-(4-(4-(3-(2-(4-chlorophenyl)-1-isopropyl-5-methyl-4-(methylsulfonyl)-1H-pyrrol-3-yl)-5-fluorophenyl)piperazin-1-yl)phenyl)-4-fluoro-3-(trifluoromethylsulfonyl)benzenesulfonamide

: 1619923-57-7
(R)-4-(4-(methylthiomethoxy)piperidin-1-yl)-1-(phenylthio)butan-2-amine

: 1619923-27-1
(R)-(1-(3-(4-(N-(4-(4-(3-(2-(4-chlorophenyl)-1-isopropyl-5-methyl-4-(methylsulfonyl)-1H-pyrrol-3-yl)-5-fluorophenyl)piperazin-1-yl)phenyl) sulfamoyl)-2(trifluoromethylsulfonyl)phenylamino)-4-(phenylthio)butyl)piperidin-4-yloxy)methyl dihydrogen phosphate

Guidance literature:: N-(4-(4-(3-(2-(4-chlorophenyl)-1-isopropyl-5-methyl-4-(methylsulfonyl)-1H-pyrrol-3-yl)-5-fluorophenyl)piperazin-1-yl)phenyl)-4-fluoro-3-(trifluoromethylsulfonyl)benzenesulfonamide; (R)-4-(4-(methylthiomethoxy)piperidin-1-yl)-1-(phenylthio)butan-2-amine; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

With N-iodo-succinimide; phosphoric acid; In tetrahydrofuran; at 0 - 20 ℃; for 1h;

Reference yield:

: 1027345-07-8
4-fluoro-3-(trifluoromethylsulfonyl)benzene-1-sulfonyl chloride

: 1619923-27-1
(R)-(1-(3-(4-(N-(4-(4-(3-(2-(4-chlorophenyl)-1-isopropyl-5-methyl-4-(methylsulfonyl)-1H-pyrrol-3-yl)-5-fluorophenyl)piperazin-1-yl)phenyl) sulfamoyl)-2(trifluoromethylsulfonyl)phenylamino)-4-(phenylthio)butyl)piperidin-4-yloxy)methyl dihydrogen phosphate

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogen; palladium on activated charcoal / methanol / 0.33 h / 20 °C

1.2: 1 h / 0 - 20 °C

2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 4 h / 20 °C

2.2: molecular sieves 4? / 1 h / 0 - 20 °C

With palladium on activated charcoal; hydrogen; N-ethyl-N,N-diisopropylamine; In methanol; N,N-dimethyl-formamide;

Reference yield:

: 1619923-52-2
1-[3-[2-(4-chlorophenyl)-1-isopropyl-5-methyl-4-methylsulfonyl-pyrrol-3-yl]-5-fluoro-phenyl]-4-(4-nitrophenyl)piperazine

: 1619923-27-1
(R)-(1-(3-(4-(N-(4-(4-(3-(2-(4-chlorophenyl)-1-isopropyl-5-methyl-4-(methylsulfonyl)-1H-pyrrol-3-yl)-5-fluorophenyl)piperazin-1-yl)phenyl) sulfamoyl)-2(trifluoromethylsulfonyl)phenylamino)-4-(phenylthio)butyl)piperidin-4-yloxy)methyl dihydrogen phosphate

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogen; palladium on activated charcoal / methanol / 0.33 h / 20 °C

1.2: 1 h / 0 - 20 °C

2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 4 h / 20 °C

2.2: molecular sieves 4? / 1 h / 0 - 20 °C

With palladium on activated charcoal; hydrogen; N-ethyl-N,N-diisopropylamine; In methanol; N,N-dimethyl-formamide;