N-(4-(4-(3-(2-(4-chlorophenyl)-1-isopropyl-5-methyl-4-(methylsulfonyl)-1H-pyrrol-3-yl)-5-fluorophenyl)piperazin-1-yl)phenyl)-4-fluoro-3-(trifluoromethylsulfonyl)benzenesulfonamide

Base Information

Chemical Name:N-(4-(4-(3-(2-(4-chlorophenyl)-1-isopropyl-5-methyl-4-(methylsulfonyl)-1H-pyrrol-3-yl)-5-fluorophenyl)piperazin-1-yl)phenyl)-4-fluoro-3-(trifluoromethylsulfonyl)benzenesulfonamide
CAS No.:1619923-53-3
Molecular Formula:C₃₈H₃₆ClF₅N₄O₆S₃
Molecular Weight:871.37
Hs Code.:

N-(4-(4-(3-(2-(4-chlorophenyl)-1-isopropyl-5-methyl-4-(methylsulfonyl)-1H-pyrrol-3-yl)-5-fluorophenyl)piperazin-1-yl)phenyl)-4-fluoro-3-(trifluoromethylsulfonyl)benzenesulfonamide

Synonyms:N-(4-(4-(3-(2-(4-chlorophenyl)-1-isopropyl-5-methyl-4-(methylsulfonyl)-1H-pyrrol-3-yl)-5-fluorophenyl)piperazin-1-yl)phenyl)-4-fluoro-3-(trifluoromethylsulfonyl)benzenesulfonamide

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Chemical Property of N-(4-(4-(3-(2-(4-chlorophenyl)-1-isopropyl-5-methyl-4-(methylsulfonyl)-1H-pyrrol-3-yl)-5-fluorophenyl)piperazin-1-yl)phenyl)-4-fluoro-3-(trifluoromethylsulfonyl)benzenesulfonamide

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Technology Process of N-(4-(4-(3-(2-(4-chlorophenyl)-1-isopropyl-5-methyl-4-(methylsulfonyl)-1H-pyrrol-3-yl)-5-fluorophenyl)piperazin-1-yl)phenyl)-4-fluoro-3-(trifluoromethylsulfonyl)benzenesulfonamide

There total 24 articles about N-(4-(4-(3-(2-(4-chlorophenyl)-1-isopropyl-5-methyl-4-(methylsulfonyl)-1H-pyrrol-3-yl)-5-fluorophenyl)piperazin-1-yl)phenyl)-4-fluoro-3-(trifluoromethylsulfonyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1027345-07-8
4-fluoro-3-(trifluoromethylsulfonyl)benzene-1-sulfonyl chloride

: 4-(4-(3-(2-(4-chlorophenyl)-1-isopropyl-5-methyl-4-(methylsulfonyl)-1H-pyrrol-3-yl)-5-fluorophenyl)piperazin-1-yl)aniline

: 1619923-53-3
N-(4-(4-(3-(2-(4-chlorophenyl)-1-isopropyl-5-methyl-4-(methylsulfonyl)-1H-pyrrol-3-yl)-5-fluorophenyl)piperazin-1-yl)phenyl)-4-fluoro-3-(trifluoromethylsulfonyl)benzenesulfonamide

Guidance literature:: With pyridine; In dichloromethane; at -5 ℃; Reagent/catalyst;

Reference yield:

: 1027345-07-8
4-fluoro-3-(trifluoromethylsulfonyl)benzene-1-sulfonyl chloride

: 1619923-52-2
1-[3-[2-(4-chlorophenyl)-1-isopropyl-5-methyl-4-methylsulfonyl-pyrrol-3-yl]-5-fluoro-phenyl]-4-(4-nitrophenyl)piperazine

: 1619923-53-3
N-(4-(4-(3-(2-(4-chlorophenyl)-1-isopropyl-5-methyl-4-(methylsulfonyl)-1H-pyrrol-3-yl)-5-fluorophenyl)piperazin-1-yl)phenyl)-4-fluoro-3-(trifluoromethylsulfonyl)benzenesulfonamide

Guidance literature:: 1-[3-[2-(4-chlorophenyl)-1-isopropyl-5-methyl-4-methylsulfonyl-pyrrol-3-yl]-5-fluoro-phenyl]-4-(4-nitrophenyl)piperazine; With palladium on activated charcoal; hydrogen; In methanol; at 20 ℃; for 0.333333h;

4-fluoro-3-(trifluoromethylsulfonyl)benzene-1-sulfonyl chloride; With pyridine; In methanol; at 0 - 20 ℃; for 1h;

Reference yield:

: 188813-02-7
3-bromo-5-fluorobenzaldehyde

: 1619923-53-3
N-(4-(4-(3-(2-(4-chlorophenyl)-1-isopropyl-5-methyl-4-(methylsulfonyl)-1H-pyrrol-3-yl)-5-fluorophenyl)piperazin-1-yl)phenyl)-4-fluoro-3-(trifluoromethylsulfonyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 10 steps

1: piperidine; acetic acid / toluene / Reflux

2: triethylamine; 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide / ethanol / 70 °C

3: acetic acid / methanol / 50 °C

4: copper(l) iodide; L-proline; potassium carbonate / dimethyl sulfoxide / 120 °C

5: sodium hydroxide; water / ethanol; 1,4-dioxane / 48 h / Reflux

6: trifluoroacetic acid / dichloromethane

7: N-iodo-succinimide / N,N-dimethyl-formamide / 0 °C

8: copper(l) iodide; L-proline; sodium hydroxide / dimethyl sulfoxide / 90 °C / Inert atmosphere

9: ammonium chloride; iron / ethanol / Reflux

10: pyridine / dichloromethane / -5 °C

With piperidine; pyridine; N-iodo-succinimide; copper(l) iodide; water; iron; 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; potassium carbonate; ammonium chloride; acetic acid; triethylamine; trifluoroacetic acid; L-proline; sodium hydroxide; In 1,4-dioxane; methanol; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;