4-Fluoro-3-(trifluoromethylsulfonyl)benzenesulfonyl Chloride

Base Information

• Chemical Name: 4-Fluoro-3-(trifluoromethylsulfonyl)benzenesulfonyl Chloride
• CAS No.: 1027345-07-8
• Molecular Formula: C7H3ClF4O4S2
• Molecular Weight: 326.677
• Hs Code.: 2904909090
• Mol file: 1027345-07-8.mol

Synonyms:4-Fluoro-3-(trifluoromethylsulfonyl)benzenesulfonyl Chloride;4-fluoro-3-((trifluoroMethyl)sulfonyl)benzene-1-sulfonyl chloride

Chemical Property of 4-Fluoro-3-(trifluoromethylsulfonyl)benzenesulfonyl Chloride

Chemical Property:

• Boiling Point: 397.1±42.0 °C(Predicted)
• PSA: 85.04000
• Density: 1.733±0.06 g/cm3(Predicted)
• LogP: 4.20830
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

4-Fluoro-3-(trifluoromethylsulfonyl)benzenesulfonylChloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Fluoro-3-(trifluoromethylsulfonyl)benzenesulfonyl Chloride

There total 8 articles about 4-Fluoro-3-(trifluoromethylsulfonyl)benzenesulfonyl Chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

1-fluoro-2-[(trifluoromethyl)sulfonyl]benzene (2358-41-0) → 4-fluoro-3-(trifluoromethylsulfonyl)benzene-1-sulfonyl chloride (1027345-07-8)

Guidance literature:

With chlorosulfonic acid; at 120 ℃; for 5h;

Reference yield:

2-fluorobenzenesulfonyl chloride (2905-21-7) → 4-fluoro-3-(trifluoromethylsulfonyl)benzene-1-sulfonyl chloride (1027345-07-8)

Guidance literature:

Multi-step reaction with 3 steps

1: cesium fluoride

2: tris(dimethylamino)sulfonium trimethylsilyldifluoride

3: chlorosulfonic acid / 120 °C

With chlorosulfonic acid; tris(dimethylamino)sulfonium trimethylsilyldifluoride; cesium fluoride;

Reference yield:

2-fluorothiophenol (2557-78-0) → 4-fluoro-3-(trifluoromethylsulfonyl)benzene-1-sulfonyl chloride (1027345-07-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: paraquat dichloride / N,N-dimethyl-formamide / 0.33 h / -20 °C

1.2: 20 °C

2.1: ruthenium trichloride; sodium periodate / water; acetonitrile / 3 h / 20 °C / Cooling with ice

3.1: chlorosulfonic acid / 5 h / 120 °C

With chlorosulfonic acid; ruthenium trichloride; sodium periodate; paraquat dichloride; In water; N,N-dimethyl-formamide; acetonitrile;

upstream raw materials:

1-fluoro-2-[(trifluoromethyl)sulfonyl]benzene

2-fluorothiophenol

1-fluoro-2-(trifluoromethylsulfanyl)benzene

2-nitro-aniline

Downstream raw materials:

4-fluoro-3-[(trifluoromethyl)sulfonyl]benzenesulfonamide

5-(4-chlorophenyl)-4-(3-(4-(4-(4-fluoro-3-(trifluoromethylsulfonyl)phenylsulfonamido)phenyl)piperazin-1-yl)-phenyl)-2-methyl-1-propyl-1H-pyrrole-3-carboxylic acid

1-butyl-5-(4-chlorophenyl)-4-(3-(4-(4-(4-fluoro-3-(trifluoromethylsulfonyl)phenylsulfonamido)phenyl)piperazin-1-yl)-phenyl)-2-methyl-1H-pyrrole-3-carboxylic acid

5-(4-chlorophenyl)-1-ethyl-4-(3-(4-(4-(4-fluoro-3-(trifluoromethylsulfonyl)phenylsulfonamido)phenyl)piperazin-1-yl)-phenyl)-2-methyl-1H-pyrrole-3-carboxylic acid