(2S,6R)-2-[(S)-5-{[(1R,2R)-1-(tert-Butyl-diphenyl-silanyloxymethyl)-2-methyl-but-3-enyloxy]-dimethyl-silanyloxy}-2-(4-methoxy-benzyloxy)-hept-6-enyl]-6-iodomethyl-tetrahydro-pyran

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Chemical Name:(2S,6R)-2-[(S)-5-{[(1R,2R)-1-(tert-Butyl-diphenyl-silanyloxymethyl)-2-methyl-but-3-enyloxy]-dimethyl-silanyloxy}-2-(4-methoxy-benzyloxy)-hept-6-enyl]-6-iodomethyl-tetrahydro-pyran
CAS No.:477953-54-1
Molecular Formula:C₄₅H₆₅IO₆Si₂
Molecular Weight:885.083
Hs Code.:

(2S,6R)-2-[(S)-5-{[(1R,2R)-1-(tert-Butyl-diphenyl-silanyloxymethyl)-2-methyl-but-3-enyloxy]-dimethyl-silanyloxy}-2-(4-methoxy-benzyloxy)-hept-6-enyl]-6-iodomethyl-tetrahydro-pyran

Synonyms:(2S,6R)-2-[(S)-5-{[(1R,2R)-1-(tert-Butyl-diphenyl-silanyloxymethyl)-2-methyl-but-3-enyloxy]-dimethyl-silanyloxy}-2-(4-methoxy-benzyloxy)-hept-6-enyl]-6-iodomethyl-tetrahydro-pyran

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Chemical Property of (2S,6R)-2-[(S)-5-{[(1R,2R)-1-(tert-Butyl-diphenyl-silanyloxymethyl)-2-methyl-but-3-enyloxy]-dimethyl-silanyloxy}-2-(4-methoxy-benzyloxy)-hept-6-enyl]-6-iodomethyl-tetrahydro-pyran

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Technology Process of (2S,6R)-2-[(S)-5-{[(1R,2R)-1-(tert-Butyl-diphenyl-silanyloxymethyl)-2-methyl-but-3-enyloxy]-dimethyl-silanyloxy}-2-(4-methoxy-benzyloxy)-hept-6-enyl]-6-iodomethyl-tetrahydro-pyran

There total 1 articles about (2S,6R)-2-[(S)-5-{[(1R,2R)-1-(tert-Butyl-diphenyl-silanyloxymethyl)-2-methyl-but-3-enyloxy]-dimethyl-silanyloxy}-2-(4-methoxy-benzyloxy)-hept-6-enyl]-6-iodomethyl-tetrahydro-pyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₄H₃₅ClO₂Si₂

: 477953-53-0
(S)-7-((2S,6R)-6-Iodomethyl-tetrahydro-pyran-2-yl)-6-(4-methoxy-benzyloxy)-hept-1-en-3-ol

: 477953-54-1
(2S,6R)-2-[(S)-5-{[(1R,2R)-1-(tert-Butyl-diphenyl-silanyloxymethyl)-2-methyl-but-3-enyloxy]-dimethyl-silanyloxy}-2-(4-methoxy-benzyloxy)-hept-6-enyl]-6-iodomethyl-tetrahydro-pyran

Guidance literature:: With 1H-imidazole; In tetrahydrofuran; at 20 ℃; for 16h;
DOI:10.1021/ol0268438

Reference yield:

: 477953-54-1
(2S,6R)-2-[(S)-5-{[(1R,2R)-1-(tert-Butyl-diphenyl-silanyloxymethyl)-2-methyl-but-3-enyloxy]-dimethyl-silanyloxy}-2-(4-methoxy-benzyloxy)-hept-6-enyl]-6-iodomethyl-tetrahydro-pyran

: (Z)-(4R,5R,8S)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-8-[(S)-4-((2S,6R)-6-iodomethyl-tetrahydro-pyran-2-yl)-3-(4-methoxy-benzyloxy)-butyl]-2,2,5-trimethyl-5,8-dihydro-4H-[1,3,2]dioxasilocine

Guidance literature:: bis[1,1-di(trifluoromethyl)ethoxy][(2,6-diisopropylphenyl)imino](2-methyl-2-phenylpropylidene)molybdenum; In benzene; at 20 ℃; for 24h;
DOI:10.1021/ol0268438

Reference yield:

: 477953-54-1
(2S,6R)-2-[(S)-5-{[(1R,2R)-1-(tert-Butyl-diphenyl-silanyloxymethyl)-2-methyl-but-3-enyloxy]-dimethyl-silanyloxy}-2-(4-methoxy-benzyloxy)-hept-6-enyl]-6-iodomethyl-tetrahydro-pyran

: tert-Butyl-[(2S,5S,7R,8R)-2-((2S,6R)-6-iodomethyl-tetrahydro-pyran-2-ylmethyl)-8-methyl-1,6-dioxa-spiro[4.5]dec-7-ylmethoxy]-diphenyl-silane

Guidance literature:: Multi-step reaction with 5 steps

1: Schrock's molybdenum catalyst / benzene / 24 h / 20 °C

2: TFA / tetrahydrofuran; methanol / 24 h / 20 °C

3: MnO₂ / ethyl acetate / 24 h / 20 °C

4: H₂ / Pd/C / ethyl acetate / 4 h / 20 °C

5: DDQ / CH₂Cl₂; H₂O / 0.5 h / 20 °C

With manganese(IV) oxide; hydrogen; trifluoroacetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; palladium on activated charcoal; bis[1,1-di(trifluoromethyl)ethoxy][(2,6-diisopropylphenyl)imino](2-methyl-2-phenylpropylidene)molybdenum; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; benzene;
DOI:10.1021/ol0268438