(S)-7-((2S,6R)-6-Iodomethyl-tetrahydro-pyran-2-yl)-6-(4-methoxy-benzyloxy)-hept-1-en-3-ol

Base Information

Chemical Name:(S)-7-((2S,6R)-6-Iodomethyl-tetrahydro-pyran-2-yl)-6-(4-methoxy-benzyloxy)-hept-1-en-3-ol
CAS No.:477953-53-0
Molecular Formula:C₂₁H₃₁IO₄
Molecular Weight:474.379
Hs Code.:

Synonyms:(S)-7-((2S,6R)-6-Iodomethyl-tetrahydro-pyran-2-yl)-6-(4-methoxy-benzyloxy)-hept-1-en-3-ol

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Chemical Property of (S)-7-((2S,6R)-6-Iodomethyl-tetrahydro-pyran-2-yl)-6-(4-methoxy-benzyloxy)-hept-1-en-3-ol

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Technology Process of (S)-7-((2S,6R)-6-Iodomethyl-tetrahydro-pyran-2-yl)-6-(4-methoxy-benzyloxy)-hept-1-en-3-ol

There total 2 articles about (S)-7-((2S,6R)-6-Iodomethyl-tetrahydro-pyran-2-yl)-6-(4-methoxy-benzyloxy)-hept-1-en-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 477953-52-9
(2R,6S)-2-Iodomethyl-6-[(S)-2-(4-methoxy-benzyloxy)-hept-6-enyl]-tetrahydro-pyran

: 477953-53-0
(S)-7-((2S,6R)-6-Iodomethyl-tetrahydro-pyran-2-yl)-6-(4-methoxy-benzyloxy)-hept-1-en-3-ol

Guidance literature:: With tert.-butylhydroperoxide; selenium(IV) oxide; In dichloromethane; at 20 ℃; for 288h;
DOI:10.1021/ol0268438

Reference yield:

: 477953-51-8
(6S,8S)-8-(4-Methoxy-benzyloxy)-trideca-1,12-dien-6-ol

: (S)-7-((2S,6S)-6-Iodomethyl-tetrahydro-pyran-2-yl)-6-(4-methoxy-benzyloxy)-hept-1-en-3-ol

: 477953-53-0
(S)-7-((2S,6R)-6-Iodomethyl-tetrahydro-pyran-2-yl)-6-(4-methoxy-benzyloxy)-hept-1-en-3-ol

Guidance literature:: (6S,8S)-8-(4-Methoxy-benzyloxy)-trideca-1,12-dien-6-ol; With N-iodo-succinimide; potassium carbonate; In dichloromethane; at 20 ℃; for 16h;

With tert.-butylhydroperoxide; selenium(IV) oxide; In dichloromethane; at 20 ℃; for 288h; Further stages.;
DOI:10.1021/ol0268438

Reference yield:

: 477953-53-0
(S)-7-((2S,6R)-6-Iodomethyl-tetrahydro-pyran-2-yl)-6-(4-methoxy-benzyloxy)-hept-1-en-3-ol

: 477953-56-3
(Z)-(2R,3R,6S,9S)-1-(tert-Butyl-diphenyl-silanyloxy)-10-((2S,6R)-6-iodomethyl-tetrahydro-pyran-2-yl)-9-(4-methoxy-benzyloxy)-3-methyl-dec-4-ene-2,6-diol

Guidance literature:: Multi-step reaction with 3 steps

1: imidazole / tetrahydrofuran / 16 h / 20 °C

2: Schrock's molybdenum catalyst / benzene / 24 h / 20 °C

3: TFA / tetrahydrofuran; methanol / 24 h / 20 °C

With 1H-imidazole; trifluoroacetic acid; bis[1,1-di(trifluoromethyl)ethoxy][(2,6-diisopropylphenyl)imino](2-methyl-2-phenylpropylidene)molybdenum; In tetrahydrofuran; methanol; benzene;
DOI:10.1021/ol0268438