(S)-(-)-N-trifluoroacetyl-1-(8-bromo-2,3,6,7-tetrahydrobenzo[1,2-b;4,5-b']difuran-4-yl)-2-aminopropane

Base Information

• Chemical Name: (S)-(-)-N-trifluoroacetyl-1-(8-bromo-2,3,6,7-tetrahydrobenzo[1,2-b;4,5-b']difuran-4-yl)-2-aminopropane
• CAS No.: 332012-13-2
• Molecular Formula: C₁₅H₁₅BrF₃NO₃
• Molecular Weight: 394.188

Synonyms:(S)-(-)-N-trifluoroacetyl-1-(8-bromo-2,3,6,7-tetrahydrobenzo[1,2-b;4,5-b']difuran-4-yl)-2-aminopropane

Chemical Property of (S)-(-)-N-trifluoroacetyl-1-(8-bromo-2,3,6,7-tetrahydrobenzo[1,2-b;4,5-b']difuran-4-yl)-2-aminopropane

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Technology Process of (S)-(-)-N-trifluoroacetyl-1-(8-bromo-2,3,6,7-tetrahydrobenzo[1,2-b;4,5-b']difuran-4-yl)-2-aminopropane

There total 1 articles about (S)-(-)-N-trifluoroacetyl-1-(8-bromo-2,3,6,7-tetrahydrobenzo[1,2-b;4,5-b']difuran-4-yl)-2-aminopropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4,10-dioxatricyclo[7.3.0.03,7]dodeca-1,3(7),8-triene (81926-24-1) → (S)-(-)-N-trifluoroacetyl-1-(8-bromo-2,3,6,7-tetrahydrobenzo[1,2-b;4,5-b']difuran-4-yl)-2-aminopropane (332012-13-2)

Guidance literature:

Multi-step reaction with 3 steps

1: AlCl₃ / CH₂Cl₂ / 16 h

2: 94 percent / TFA; Et₃SiH / 6 h / Heating

3: 82 percent / Br₂ / acetic acid / 4.5 h / 20 °C

With triethylsilane; aluminium trichloride; bromine; trifluoroacetic acid; In dichloromethane; acetic acid; 1: Friedel-Crafts acylation;

DOI:10.1021/jm000491y

Reference yield:

(S)-(-)-N-trifluoroacetyl-1-(8-bromo-2,3,6,7-tetrahydrobenzo[1,2-b;4,5-b']difuran-4-yl)-2-aminopropane (332012-13-2) → (S)-(+)-1-(8-bromo-2,3,6,7-tetrahydrobenzo[1,2-b;4,5-b']difuran-4-yl)-2-aminopropane (219986-75-1)

Guidance literature:

With sodium hydroxide; In methanol;

DOI:10.1021/jm000491y

upstream raw materials:

4,10-dioxatricyclo[7.3.0.0^3,7]dodeca-1,3⁽⁷⁾,8-triene

Downstream raw materials:

(S)-(+)-1-(8-bromo-2,3,6,7-tetrahydrobenzo[1,2-b;4,5-b']difuran-4-yl)-2-aminopropane

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