219986-75-1 Usage
Uses
Used in Pharmaceutical Research:
2-(8-Bromo-2,3,6,7-tetrahydro-benzo[1,2-b:4,5-b']difuran-4-yl)-1-methyl-ethylamine is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique structure allows it to be a candidate for the development of new drugs, particularly in the areas of medicinal chemistry and drug discovery.
Used in Organic Chemistry:
In the field of organic chemistry, 2-(8-Bromo-2,3,6,7-tetrahydro-benzo[1,2-b:4,5-b']difuran-4-yl)-1-methyl-ethylamine serves as a reagent or building block in the synthesis of more complex organic molecules. Its presence of different functional groups makes it a versatile component in organic synthesis.
Used in Materials Science:
2-(8-Bromo-2,3,6,7-tetrahydro-benzo[1,2-b:4,5-b']difuran-4-yl)-1-methyl-ethylamine may be utilized in materials science for the development of new materials with specific properties. Its structural components could contribute to the creation of materials with unique characteristics for various applications.
Used as a Research Tool in Biochemistry:
2-(8-BROMO-2,3,6,7-TETRAHYDRO-BENZO[1,2-B:4,5-B']DIFURAN-4-YL)-1-METHYL-ETHYLAMINE can be employed as a research tool in biochemistry to study the interactions of molecules with biological systems. Its complex structure may provide insights into molecular recognition and binding processes, aiding in the understanding of biochemical mechanisms.
Used in Chemical Education:
2-(8-Bromo-2,3,6,7-tetrahydro-benzo[1,2-b:4,5-b']difuran-4-yl)-1-methyl-ethylamine can be used in educational settings to teach students about the synthesis, properties, and applications of complex organic compounds, enhancing their understanding of organic and medicinal chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 219986-75-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,9,9,8 and 6 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 219986-75:
(8*2)+(7*1)+(6*9)+(5*9)+(4*8)+(3*6)+(2*7)+(1*5)=191
191 % 10 = 1
So 219986-75-1 is a valid CAS Registry Number.
219986-75-1Relevant academic research and scientific papers
Enantiospecific synthesis and pharmacological evaluation of a series of super-potent, conformationally restricted 5-HT2A/2C receptor agonists
Chambers,Kurrasch-Orbaugh,Parker,Nichols
, p. 1003 - 1010 (2007/10/03)
The affinity of ligands for either the 5-HT2A or 5-HT2C agonist binding site was enhanced by modification of the 2,5-oxygen substituents that are found in typical hallucinogenic amphetamines such as 4b (DOB). Restriction of the conformationally flexible 2,5-dimethoxy substituents into fused dihydrofuran rings generally resulted in increased potency relative to the parent 2,5-dimethoxy compounds. The pure enantiomers of these arylalkylamines were obtained by enantiospecific synthesis that involved acylation of the heterocyclic nucleus 7 with N-trifluoroacetyl-protected D- or L-alanyl chloride, followed by ketone reduction and N-deprotection. The enantiomers demonstrated modest stereoselectivity at the two receptors. Several general trends within these classes of new compounds were observed during their pharmacological investigation. For most pairs of optical isomers tested, the R-enantiomers of the compounds containing heterocycle 7 bound with only slightly higher affinity than their S-antipodes at the 5-HT2A and 5-HT2C receptors. Likewise, functional studies indicated that the R-enantiomers generally displayed increased potency compared to the S-enantiomers. Aromatization of the dihydrofuran rings of these arylalkylamines further increased affinity and potency. Only a few compounds were full agonists with most of them possessing intrinsic activities in the range of 60-80%. These compounds with a fully aromatic linear tricyclic nucleus are some of the highest-affinity ligands for the 5-HT2A receptor reported to date.
