2-(4-Methoxy-phenyl)-2-(4-nitro-imidazol-1-yl)-propionic acid ethyl ester

Base Information

• Chemical Name: 2-(4-Methoxy-phenyl)-2-(4-nitro-imidazol-1-yl)-propionic acid ethyl ester
• CAS No.: 220536-10-7
• Molecular Formula: C₁₅H₁₇N₃O₅
• Molecular Weight: 319.317
• Mol file: 220536-10-7.mol

Synonyms:2-(4-Methoxy-phenyl)-2-(4-nitro-imidazol-1-yl)-propionic acid ethyl ester

Chemical Property of 2-(4-Methoxy-phenyl)-2-(4-nitro-imidazol-1-yl)-propionic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-Methoxy-phenyl)-2-(4-nitro-imidazol-1-yl)-propionic acid ethyl ester

There total 4 articles about 2-(4-Methoxy-phenyl)-2-(4-nitro-imidazol-1-yl)-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

methyl iodide (74-88-4) + (methoxy-phenyl)-(4-nitro-imidazol-1-yl)-acetic acid ethyl ester (220529-51-1) → 2-(4-Methoxy-phenyl)-2-(4-nitro-imidazol-1-yl)-propionic acid ethyl ester (220536-10-7)

Guidance literature:

(methoxy-phenyl)-(4-nitro-imidazol-1-yl)-acetic acid ethyl ester; With sodium hexamethyldisilazane;

methyl iodide;

DOI:10.1016/j.bmcl.2004.09.027

Reference yield: 92.0%

→ 2-(4-Methoxy-phenyl)-2-(4-nitro-imidazol-1-yl)-propionic acid ethyl ester (220536-10-7)

Guidance literature:

Reference yield:

ethyl p-methoxyphenylacetate (14062-18-1) → 2-(4-Methoxy-phenyl)-2-(4-nitro-imidazol-1-yl)-propionic acid ethyl ester (220536-10-7)

Guidance literature:

Multi-step reaction with 3 steps

1: N-bromosuccinimide; AIBN

2: K₂CO₃

3: 92 percent / sodium bis(trimethylsilyl)amide

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sodium hexamethyldisilazane; potassium carbonate;

DOI:10.1016/j.bmcl.2004.09.027

upstream raw materials:

methyl iodide

(methoxy-phenyl)-(4-nitro-imidazol-1-yl)-acetic acid ethyl ester

ethyl p-methoxyphenylacetate

ethyl 2-bromo-2-(4-methoxyphenyl) acetate

Downstream raw materials:

[1-(1-{1-[1-(4-methoxy-phenyl)-1-methyl-2-oxo-2-pyrrolidin-1-yl-ethyl]-1H-imidazol-4-ylcarbamoyl}-4-phenyl-butylcarbamoyl)-1-methyl-ethyl]-carbamic acid tert-butyl ester

3-[2-(4-methoxy-phenyl)-2-(4-nitro-imidazol-1-yl)-propionyl]-4-methyl-5-phenyl-oxazolidin-2-one

2-(4-methoxy-phenyl)-2-(4-nitro-imidazol-1-yl)-1-pyrrolidin-1-yl-propan-1-one

(R)-2-(4-Methoxy-phenyl)-2-(4-nitro-imidazol-1-yl)-propionic acid