N-{2-Chloro-4-[(7-hydroxy-6-methoxy-4-quinolyl)oxy]phenyl}-N'-(2,4-difluorophenyl)-urea

Base Information

• Chemical Name: N-{2-Chloro-4-[(7-hydroxy-6-methoxy-4-quinolyl)oxy]phenyl}-N'-(2,4-difluorophenyl)-urea
• CAS No.: 286371-55-9
• Molecular Formula: C₂₃H₁₆ClF₂N₃O₄
• Molecular Weight: 471.848

Synonyms:N-{2-Chloro-4-[(7-hydroxy-6-methoxy-4-quinolyl)oxy]phenyl}-N'-(2,4-difluorophenyl)-urea

Chemical Property of N-{2-Chloro-4-[(7-hydroxy-6-methoxy-4-quinolyl)oxy]phenyl}-N'-(2,4-difluorophenyl)-urea

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Technology Process of N-{2-Chloro-4-[(7-hydroxy-6-methoxy-4-quinolyl)oxy]phenyl}-N'-(2,4-difluorophenyl)-urea

There total 1 articles about N-{2-Chloro-4-[(7-hydroxy-6-methoxy-4-quinolyl)oxy]phenyl}-N'-(2,4-difluorophenyl)-urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

N-(4-{[7-(Benzyloxy)-6-methoxy-4-quinolyl]oxy}-2-chlorophenyl)-N'-(2,4-difluorophenyl)-urea (286371-54-8) → N-{2-Chloro-4-[(7-hydroxy-6-methoxy-4-quinolyl)oxy]phenyl}-N'-(2,4-difluorophenyl)-urea (286371-55-9)

Guidance literature:

palladium-carbon; In N-methyl-acetamide; ethyl acetate;

Reference yield: 72.0%

2-(1H-1,2,3-triazol-l-yl)ethyl4-methyl-1-benzenesulfonate + N-{2-Chloro-4-[(7-hydroxy-6-methoxy-4-quinolyl)oxy]phenyl}-N'-(2,4-difluorophenyl)-urea (286371-55-9) + sodium hydrogencarbonate (144-55-8) → N-[2-Chloro-4-({6-methoxy-7-[2-(1 H-1,2,3-triazol-1-yl)ethoxy]-4-quinolyl}oxy)phenyl]-N'-(2,4-difluorophenyl)urea (286371-27-5)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide;

Reference yield: 55.0%

N-{2-Chloro-4-[(7-hydroxy-6-methoxy-4-quinolyl)oxy]phenyl}-N'-(2,4-difluorophenyl)-urea (286371-55-9) + 4-picolylchloride hydrochloride (1822-51-1) + sodium hydrogencarbonate (144-55-8) → N-(2-chloro-4-{[6-methoxy-7-(pyridin-4-ylmethoxy)-4-quinolyl]oxy}phenyl)-N'-(2,4-difluorophenyl)-urea

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide;

upstream raw materials:

N-(4-{[7-(Benzyloxy)-6-methoxy-4-quinolyl]oxy}-2-chlorophenyl)-N'-(2,4-difluorophenyl)-urea

Downstream raw materials:

N-[2-Chloro-4-({6-methoxy-7-[2-(1 H-1,2,3-triazol-1-yl)ethoxy]-4-quinolyl}oxy)phenyl]-N'-(2,4-difluorophenyl)urea

N-(2-chloro-4-{[6-methoxy-7-(2-morpholinoethoxy)-4-quinolyl]oxy}phenyl)-N'-(2,4-difluorophenyl)urea

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