N-[7-(chloromethyl)-2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-hydroxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-carbamic acid phenylmethyl ester

Base Information

Chemical Name:N-[7-(chloromethyl)-2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-hydroxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-carbamic acid phenylmethyl ester
CAS No.:1380665-32-6
Molecular Formula:C₂₉H₃₀ClFN₄O₅
Molecular Weight:569.032
Hs Code.:

N-[7-(chloromethyl)-2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-hydroxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-carbamic acid phenylmethyl ester

Synonyms:N-[7-(chloromethyl)-2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-hydroxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-carbamic acid phenylmethyl ester

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Chemical Property of N-[7-(chloromethyl)-2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-hydroxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-carbamic acid phenylmethyl ester

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Technology Process of N-[7-(chloromethyl)-2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-hydroxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-carbamic acid phenylmethyl ester

There total 13 articles about N-[7-(chloromethyl)-2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-hydroxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-carbamic acid phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1380664-98-1
[2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-hydroxy-7-[[[(4-methylphenyl)sulfonyl]oxy]methyl]-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-carbamic acid phenylmethyl ester

: 1380665-32-6
N-[7-(chloromethyl)-2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-hydroxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-carbamic acid phenylmethyl ester

Guidance literature:: With tetramethlyammonium chloride; In dimethyl sulfoxide; at 80 ℃; for 96h;

Reference yield:

: 55704-60-4
4-oxo-cyclohexane-1,1-dicarboxylic acid diethyl ester

: 1380665-32-6
N-[7-(chloromethyl)-2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-hydroxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-carbamic acid phenylmethyl ester

Guidance literature:: Multi-step reaction with 12 steps

1.1: toluene-4-sulfonic acid / benzene / 48 h / 20 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 10 - 20 °C / Inert atmosphere; Cooling with acetone-dry ice

2.2: 1.5 h / -5 - 30 °C

3.1: pyridine / dmap / 48 h / 20 °C

4.1: hydrogenchloride; water / tetrahydrofuran / 3.5 h / 52 °C

5.1: ammonium hydroxide; ammonium chloride / tetrahydrofuran; methanol

6.1: sodium carbonate monohydrate / dichloromethane; water / 2.5 h / 20 °C / Inert atmosphere

7.1: hydroxylamine / water; tetrahydrofuran / 5 h / Reflux

8.1: tetrahydrofuran / Reflux

9.1: dichloromethane; xylene / 24 h / 115 °C

10.1: N,N,N',N'-tetramethylguanidine / toluene / 1.5 h / Reflux

11.1: ethanol / 22 h / 20 - 90 °C / Inert atmosphere

12.1: tetramethlyammonium chloride / dimethyl sulfoxide / 96 h / 80 °C

With pyridine; hydrogenchloride; ammonium hydroxide; lithium aluminium tetrahydride; sodium carbonate monohydrate; water; hydroxylamine; tetramethlyammonium chloride; ammonium chloride; N,N,N',N'-tetramethylguanidine; dmap; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; toluene; xylene; benzene;

Reference yield:

: 4-hydroxy-cyclohex-3-ene-1,1,3-tricarboxylic acid,triethyl ester

: 1380665-32-6
N-[7-(chloromethyl)-2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-hydroxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-carbamic acid phenylmethyl ester

Guidance literature:: Multi-step reaction with 13 steps

1.1: water; sodium chloride / dimethyl sulfoxide / 3.5 h / 160 °C / Inert atmosphere

2.1: toluene-4-sulfonic acid / benzene / 48 h / 20 °C / Inert atmosphere

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 10 - 20 °C / Inert atmosphere; Cooling with acetone-dry ice

3.2: 1.5 h / -5 - 30 °C

4.1: pyridine / dmap / 48 h / 20 °C

5.1: hydrogenchloride; water / tetrahydrofuran / 3.5 h / 52 °C

6.1: ammonium hydroxide; ammonium chloride / tetrahydrofuran; methanol

7.1: sodium carbonate monohydrate / dichloromethane; water / 2.5 h / 20 °C / Inert atmosphere

8.1: hydroxylamine / water; tetrahydrofuran / 5 h / Reflux

9.1: tetrahydrofuran / Reflux

10.1: dichloromethane; xylene / 24 h / 115 °C

11.1: N,N,N',N'-tetramethylguanidine / toluene / 1.5 h / Reflux

12.1: ethanol / 22 h / 20 - 90 °C / Inert atmosphere

13.1: tetramethlyammonium chloride / dimethyl sulfoxide / 96 h / 80 °C

With pyridine; hydrogenchloride; ammonium hydroxide; lithium aluminium tetrahydride; sodium carbonate monohydrate; water; hydroxylamine; tetramethlyammonium chloride; ammonium chloride; sodium chloride; N,N,N',N'-tetramethylguanidine; dmap; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; toluene; xylene; benzene;