N-phenyl-2-(1,1,3-trioxo-1,3-dihydro-1λ⁶-benzo[d]isothiazol-2-yl)-acetamide

Base Information

• Chemical Name: N-phenyl-2-(1,1,3-trioxo-1,3-dihydro-1λ⁶-benzo[d]isothiazol-2-yl)-acetamide
• CAS No.: 15059-17-3
• Molecular Formula: C₁₅H₁₂N₂O₄S
• Molecular Weight: 316.337
• Mol file: 15059-17-3.mol

Synonyms:N-phenyl-2-(1,1,3-trioxo-1,3-dihydro-1λ⁶-benzo[d]isothiazol-2-yl)-acetamide

Chemical Property of N-phenyl-2-(1,1,3-trioxo-1,3-dihydro-1λ⁶-benzo[d]isothiazol-2-yl)-acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-phenyl-2-(1,1,3-trioxo-1,3-dihydro-1λ⁶-benzo[d]isothiazol-2-yl)-acetamide

There total 8 articles about N-phenyl-2-(1,1,3-trioxo-1,3-dihydro-1λ⁶-benzo[d]isothiazol-2-yl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-(1,1-dioxido-3-oxobenzo[d]isothiazol-2(3H)-yl)acetic acid (52188-11-1) + aniline (62-53-3) → N-phenyl-2-(1,1,3-trioxo-1,3-dihydro-1λ6-benzo[d]isothiazol-2-yl)-acetamide (15059-17-3)

Guidance literature:

With 2-chloro-1-methyl-pyridinium iodide; benzaldehyde; triethylamine; In dichloromethane; for 16h; Reflux;

DOI:10.1016/j.bmc.2017.11.014

Reference yield:

saccharin sodium salt (128-44-9) + N-chloroacetyl-aniline (587-65-5) → N-phenyl-2-(1,1,3-trioxo-1,3-dihydro-1λ6-benzo[d]isothiazol-2-yl)-acetamide (15059-17-3)

Guidance literature:

In N,N-dimethyl-formamide; at 120 ℃; for 6h;

DOI:10.1002/jhet.5570200133

Reference yield:

potassium saccharate (10332-51-1) → N-phenyl-2-(1,1,3-trioxo-1,3-dihydro-1λ6-benzo[d]isothiazol-2-yl)-acetamide (15059-17-3)

Guidance literature:

Multi-step reaction with 2 steps

1: DMF

2: PCl₅ / diethyl ether; dioxane; tetrahydrofuran

With phosphorus pentachloride; N,N-dimethyl-formamide; In tetrahydrofuran; 1,4-dioxane; diethyl ether;

upstream raw materials:

2-(2-(Z)-hydroxyimino-2-phenyl-ethyl)-1,1-dioxo-1,2-dihydro-1λ⁶-benzo[d]isothiazol-3-one

saccharin sodium salt

N-chloroacetyl-aniline

2-(1,1-dioxido-3-oxobenzo[d]isothiazol-2(3H)-yl)acetic acid

Downstream raw materials:

2-(Phenylcarbamoylmethyl-sulfamoyl)-benzoic acid methyl ester

0-(N-phenylcarboxamidomethylsulfamyl)benzoic acid

1,1,4-trioxo-1,2,3,4-tetrahydro-1λ⁶-benzo[e][1,2]thiazine-3-carboxylic acid anilide