52188-11-1

Basic information

• Product Name: (1,1-DIOXIDO-3-OXO-1,2-BENZISOTHIAZOL-2(3H)-YL)ACETIC ACID
• Synonyms: 1,2-benzisothiazole-2(3H)-acetic acid, 3-oxo-, 1,1-dioxide;2-(1,1,3-triketo-1,2-benzothiazol-2-yl)acetic acid;2-(1,1,3-trioxo-1,2-benzothiazol-2-yl)acetic acid;2-(1,1,3-trioxo-1,2-benzothiazol-2-yl)ethanoic acid;2-(1,1-dioxido-3-oxobenzo[d]isothiazol-2(3H)-yl)acetic acid
• CAS NO: 52188-11-1
• Molecular Formula: C₉H₇NO₅S
• Molecular Weight: 241.22
• Mol File: 52188-11-1.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 514°C at 760 mmHg
• Flash Point: 264.7°C
• Appearance: /
• Density: 1.665g/cm³
• Vapor Pressure: 2.16E-11mmHg at 25°C
• Refractive Index: 1.653
• CAS DataBase Reference: (1,1-DIOXIDO-3-OXO-1,2-BENZISOTHIAZOL-2(3H)-YL)ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (1,1-DIOXIDO-3-OXO-1,2-BENZISOTHIAZOL-2(3H)-YL)ACETIC ACID(52188-11-1)
• EPA Substance Registry System: (1,1-DIOXIDO-3-OXO-1,2-BENZISOTHIAZOL-2(3H)-YL)ACETIC ACID(52188-11-1)

Safety Data

• Hazardous Substances Data: 52188-11-1(Hazardous Substances Data)

Usage

General Description

(1,1-DIOXIDO-3-OXO-1,2-BENZISOTHIAZOL-2(3H)-YL)ACETIC ACID is a chemical compound with the molecular formula C9H7NO5S. It belongs to the benzisothiazolone group of chemicals and is commonly used as a biocide and preservative in various industrial and consumer products. The compound has antimicrobial properties and is effective in controlling the growth of bacteria, fungi, and algae. It is often used in water treatment systems, cooling towers, and metalworking fluids to prevent microbial contamination. Additionally, it is also used in personal care products, such as shampoos and lotions, to inhibit the growth of bacteria and fungi. However, it is important to handle and use this chemical with caution, as it may cause skin and eye irritation and can be harmful if ingested or inhaled.

InChI:InChI=1/C9H7NO5S/c11-8(12)5-10-9(13)6-3-1-2-4-7(6)16(10,14)15/h1-4H,5H2,(H,11,12)

Upstream product

• 128-44-9 saccharin sodium salt 
• 79-11-8 chloroacetic acid 
• 79-08-3 bromoacetic acid 
• 81-08-3 2-sulfobenzoic acid cyclic anhydride 
• 56-40-6 glycine 
• 81-07-2 saccharin 
• 10332-51-1 potassium saccharate 
• 6639-62-9 methyl 3-oxo-2,3-dihydrobenzo[d][1,2]thiazol-2-acetate 1,1-dioxide 
• 220223-03-0 N-(2-carboxyphenylsulfonyl)glycine 
• 24683-20-3 ethyl 2-(1,1-dioxido-3-oxobenzo[d]isothiazol-2(3H)-yl) acetate 

Downstream Products

• 182502-68-7 SCP-1 
• 1221971-29-4 C₂₀H₁₃Cl₂N₃O₄S 
• 1431565-73-9 (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(2-(1,1-dioxido-3-oxobenzo[d]isothiazol-2(3H)-yl)acetoxy)ethyl)pyridine 1-oxide 
• 663168-19-2 C₁₇H₁₆N₂O₅S 
• 1446318-13-3 C₁₇H₁₈N₂O₆S 
• 1619983-83-3 2-[({[(2R,4aS,8aS)-4-[(3,5-dihydroxyphenyl)carbonyl]-3,4a,8,8-tetramethyldecahydronaphthalen-2-yl]carbamoyl}methyl)sulfamoyl]benzoic acid 
• 1428559-96-9 C₁₅H₁₃N₃O₇S 
• 454192-39-3 C₁₅H₁₁N₃O₆S 
• 1428559-94-7 C₁₅H₁₃N₃O₇S 

Relevant articles and documents

Structural investigation on thiazolo[5,4-d]pyrimidines to obtain dual-acting blockers of CD73 and adenosine A2A receptor as potential antitumor agents

Adenosine pathway, including its generating enzyme (CD73) and its receptors represents a key target for cancer immunotherapy. Here we aimed to search for novel compounds able to co-target the CD73 and the A2A adenosine receptor (A2A

Design, synthesis and preliminary bioactivity studies of 1,2-dihydrobenzo[d]isothiazol-3-one-1,1-dioxide hydroxamic acid derivatives as novel histone deacetylase inhibitors

Histone deacetylase (HDAC) is a clinically validated target for antitumor therapy. In order to increase HDAC inhibition and efficiency, we developed a novel series of saccharin hydroxamic acids as potent HDAC inhibitors. Among them, compounds 11e, 11m, 11

A facile and green synthesis of novel imide and amidic acid derivatives of phenacetin as potential analgesic and anti-pyretic agents

Facile and green syntheses of potential analgesic and antipyretic compounds, N-(4-ethoxy-phenyl)-2-(1,3- dioxo-1,3-dihydroisoindol-2-yl)acetamide derivatives 6a-g and N-[(4-ethoxy-phenylcarbamoyl)methyl]phthalamic acid derivatives 10a-g have been developed. Two synthetic routes (A and B) have been established for the preparation of 6a-g. In the route-A, 4-ethoxyaniline 2 was reacted with chloroacetyl chloride 3 in a solution of potassium acetate and acetic acid to yield N-(4-ethoxyphenyl)-2-chloroacetamide 4. The latter was reacted with imide compounds 5a-g either in triethanolamine as a green solvent or in solid phase in the presence of TEBAC and KI to yield 6a-g. Alternatively, in the route-B, reaction of anhydrides 7a-g with glycine 8 yielded the (1, 3-dioxo-1, 3-dihydroisoindol-2-yl)acetic acid derivatives 9a-g which on reaction with 2 either in triethnolamine and DCC as a dehydrating agent or in solid phase in the presence of DCC gave 6a-g. The latter were hydrolyzed in 0.5N ethanolic KOH to afford 10a-g.