(R)-Glycidyl-4-nitrobenzenesulfonate

Base Information

• Chemical Name: (R)-Glycidyl-4-nitrobenzenesulfonate
• CAS No.: 118629-64-4
• Molecular Formula: C₉H₉NO₆S
• Molecular Weight: 259.24
• Hs Code.: 29109000
• Mol file: 118629-64-4.mol

Synonyms:Benzenesulfonicacid, 4-nitro-, oxiranylmethyl ester (9CI); 4-Nitrobenzenesulfonic acidoxiranylmethyl ester; Glycidyl p-nitrobenzenesulfonate

Chemical Property of (R)-Glycidyl-4-nitrobenzenesulfonate

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

Useful:

Technology Process of (R)-Glycidyl-4-nitrobenzenesulfonate

There total 5 articles about (R)-Glycidyl-4-nitrobenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

4-Nitrobenzenesulfonyl chloride (98-74-8) + (S)-oxiranemethanol (60456-23-7) → (2R)-glycidyl 4-nitrobenzenesulfonate (123750-60-7,118629-64-4)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1021/jm900563e

Reference yield: 40.0%

4-Nitrobenzenesulfonyl chloride (98-74-8) + (R)-oxiranemethanol (57044-25-4) → S-oxiran-2-ylmethyl 4-nitrobenzenesulfonate (118712-60-0,118629-64-4)

Guidance literature:

With triethylamine; In toluene; at 0 - 20 ℃; for 0.5h;

DOI:10.1016/j.bmc.2015.04.034

Reference yield:

4-Nitrobenzenesulfonyl chloride (98-74-8) + (S)-oxiranemethanol (60456-23-7) → S-oxiran-2-ylmethyl 4-nitrobenzenesulfonate (118712-60-0,118629-64-4) + (2R)-glycidyl 4-nitrobenzenesulfonate (123750-60-7,118629-64-4)

Guidance literature:

With triethylamine; In toluene; at -10 ℃; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1021/jo00267a014

upstream raw materials:

4-Nitrobenzenesulfonyl chloride

(S)-oxiranemethanol

(R)-oxiranemethanol

Downstream raw materials:

(-)-Bisoprolol

(S)-3-(2-allyloxyphenoxy)-1,2-epoxypropane

(R)-1-(2'-allyloxyphenoxy)-2,3-epoxypropane

3-(4-tert-butyldimethylsilyloxyphenoxy)-2-(S)-propyleneoxide