1-(2-Methoxyethyl)benzimidazole

Base Information

• Chemical Name: 1-(2-Methoxyethyl)benzimidazole
• CAS No.: 118468-98-7
• Molecular Formula: C10H12 N2 O
• Molecular Weight: 176.218
• DSSTox Substance ID: DTXSID70365739
• Nikkaji Number: J1.554.735I
• Wikidata: Q82150659
• Mol file: 118468-98-7.mol

Synonyms:1-(2-methoxyethyl)benzimidazole;118468-98-7;1-(2-methoxyethyl)-1H-benzimidazole;SCHEMBL1024585;DTXSID70365739;JEUJFDMULHJHDL-UHFFFAOYSA-N;HMS1789N19;STL570384;AKOS001372323;Z57187094

Chemical Property of 1-(2-Methoxyethyl)benzimidazole

Chemical Property:

• PSA: 27.05000
• LogP: 1.68270
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 176.094963011
• Heavy Atom Count: 13
• Complexity: 163

Purity/Quality:

1-(2-METHOXYETHYL)BENZIMIDAZOLE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COCCN1C=NC2=CC=CC=C21

Technology Process of 1-(2-Methoxyethyl)benzimidazole

There total 5 articles about 1-(2-Methoxyethyl)benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-methoxy-ethanol (109-86-4,95507-80-5) + 1-(phenylsulfonyl)-1H-benzo[d]imidazole (15728-43-5) → 1-(2-methoxyethyl)-1H-benzo[d]imidazole (118468-98-7)

Guidance literature:

With tetrabutylammomium bromide; caesium carbonate; In toluene; at 20 ℃; Inert atmosphere; Reflux;

DOI:10.1055/S-0029-1218627

Reference yield: 87.0%

benzoimidazole (51-17-2,79351-71-6) + 2-chloroethyl methyl ether (627-42-9) → 1-(2-methoxyethyl)-1H-benzo[d]imidazole (118468-98-7)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide;

Reference yield:

benzoimidazole (51-17-2,79351-71-6) → 1-(2-methoxyethyl)-1H-benzo[d]imidazole (118468-98-7)

Guidance literature:

With potassium hydroxide; In ethanol;

DOI:10.1002/ejic.201000181

upstream raw materials:

benzoimidazole

2-chloroethyl methyl ether

2-methoxy-ethanol

1-(phenylsulfonyl)-1H-benzo[d]imidazole

Refernces

• 1、 Touj, Nedra,Al-Ayed, Abdullah S.,Sauthier, Mathieu,Mansour, Lamjed,Harrath, Abdel Halim,Al-Tamimi, Jamil,?zdemir, Ismail,Ya?ar, Sedat,Hamdi, Naceur. "Efficient in situ N-heterocyclic carbene palladium(ii) generated from Pd(OAc)2 catalysts for carbonylative Suzuki coupling reactions of arylboronic acids with 2-bromopyridine under inert conditions leading to unsymmetrical arylpyridine ketones: synthesis, characterization and cytotoxic activities". . p. 40000 - 40015. Retrieved 2018.
• 2、 Karatas, Mert Olgun,Alici, Bulent,Cetinkaya, Engin,Bilen, Cigdem,Gencer, Nahit,Arslan, Oktay. "Synthesis, characterization and tyrosinase inhibitory properties of benzimidazole derivatives". . p. 461 - 466. Retrieved 2014/08/18.