2-Chloroethyl methyl ether

Base Information

• Chemical Name: 2-Chloroethyl methyl ether
• CAS No.: 627-42-9
• Molecular Formula: C3H7ClO
• Molecular Weight: 94.541
• Hs Code.: 29091900
• European Community (EC) Number: 210-999-7
• UNII: U890TJ10YM
• DSSTox Substance ID: DTXSID6060840
• Nikkaji Number: J516I
• Wikidata: Q27290851
• Mol file: 627-42-9.mol

Synonyms:2-Chloroethyl methyl ether;627-42-9;1-Chloro-2-methoxyethane;2-Methoxyethyl chloride;Ethane, 1-chloro-2-methoxy-;1-chloro-2-methoxy-ethane;Ether, 2-chloroethyl methyl;methoxyethyl chloride;2-Methoxyethylchloride;Chloroethyl-methyl ether;methyl 2-chloroethyl ether;UNII-U890TJ10YM;Ethane, 1-chloro-2-methoxy;U890TJ10YM;HSDB 2722;BETA-CHLOROETHYL METHYL ETHER;EINECS 210-999-7;AI3-61817;Chloro-2-methoxyethane;2-Chloroethylmethylether;chloroethylmethylether;MFCD00000972;chloroethylmethyl ether;2-methyloxychloroethane;chloroethyl methyl ether;2-chloroethyl methylether;2-chloroethyl-methylether;2-chloroethylmethyl ether;2chloroethyl methyl ether;2-chloroethyl methy ether;2-chloroethyl-methyl ether;2-chloroethyl-methyl-ether;1-(2-chloroethoxy)methane;1-Chloro-2-methoxyethane #;1-chloro-2-(methyloxy)ethane;DTXSID6060840;2-CHLORO-1-METHOXYETHANE;2-Chloroethyl methyl ether, 98%;AMY25739;STL146567;AKOS000121076;.BETA.-CHLOROETHYL METHYL ETHER;ETHYLENECHLOROHYDRIN METHYL ETHER;1-CHLORO-2-METHOXYETHANE [HSDB];FT-0612849;EN300-23908;E77037;W-104961;Q27290851;F0001-1686

Chemical Property of 2-Chloroethyl methyl ether

Chemical Property:

• Appearance/Colour: clear colorless to yellowish liquid
• Melting Point: -55 °C
• Refractive Index: n20/D 1.408(lit.)
• Boiling Point: 92.5 °C at 760 mmHg
• Flash Point: 15 °C
• PSA: 9.23000
• Density: 0.986 g/cm³
• LogP: 0.87160
• Storage Temp.: Flammables area
• Solubility.: 80g/l
• Water Solubility.: 60 g/L (20 C)
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 94.0185425
• Heavy Atom Count: 5
• Complexity: 16.4

Purity/Quality:

99% ^*data from raw suppliers

2-Chloroethyl Methyl Ether ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F; Xn
• Hazard Codes: F,Xn
• Statements: 11-20/21/22-22
• Safety Statements: 36/37-23-16

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Other Classes -> Halogenated Ethers
• Canonical SMILES: COCCCl
• Uses: 2-Chloroethyl Methyl Ether is used as a reagent in the synthesis of Piperonyl Methoxyethyl Ether (P490475); a selective inhibitor of the cytochrome P450-dependent monooxygenase from the housefly. 2-Chloroethyl methyl ether was used in the synthesis of acyclic nucleosides of thieno[2,3-d] pyrimidine derivatives. 2-Chloroethyl methyl ether (2-Methoxyethyl chloride) was used in the synthesis of acyclic nucleosides of thieno[2,3-d]pyrimidine derivatives.

Technology Process of 2-Chloroethyl methyl ether

There total 19 articles about 2-Chloroethyl methyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

→ 1,2-dimethoxyethane (110-71-4) + 2-chloroethyl methyl ether (627-42-9)

Guidance literature:

Reference yield: 43.0%

dimethyl sulfate (77-78-1) + 2-chloro-ethanol (107-07-3) → 2-chloroethyl methyl ether (627-42-9)

Guidance literature:

With calcium carbonate; at 120 - 130 ℃;

DOI:10.1016/j.bmcl.2017.02.059

Reference yield:

2-methoxy-ethanol (109-86-4,95507-80-5) → 2-chloroethyl methyl ether (627-42-9)

Guidance literature:

With pyridine; phosphorus trichloride;

upstream raw materials:

diazomethane

2-chloro-ethanol

methanol

N,N-Dichlorobenzenesulfonamide

Downstream raw materials:

N-{5-[4-(2-methoxy-ethylamino)-phenoxy]-pentyl}-phthalimide

N-(ethoxymethyl)-4-methylbenzenesulfonamide

1-methoxy-2-phenylethane

3-(2-methoxyethoxy)benzaldehyde

Refernces

• 1、 -. "4-anilinoquinazoline derivative and albumin conjugates thereof". Page/Page column 8. . Retrieved 2019/04/26.
• 2、 Boobalan, Ramalingam,Liu, Kuang-Kai,Chao, Jui-I.,Chen, Chinpiao. "Synthesis and biological assay of erlotinib analogues and BSA-conjugated erlotinib analogue". supporting information. p. 1784 - 1788. Retrieved 2017/04/04.