5'-O-(4,4'-dimethoxytrityl)thymidylyl-(3'-5'-carbamoyl)-5'-amino-2'-O,5'-N-cyclo-5'-deoxyarabinouridine

Base Information

Chemical Name:5'-O-(4,4'-dimethoxytrityl)thymidylyl-(3'-5'-carbamoyl)-5'-amino-2'-O,5'-N-cyclo-5'-deoxyarabinouridine
CAS No.:1080623-55-7
Molecular Formula:C₄₁H₄₁N₅O₁₃
Molecular Weight:811.802
Hs Code.:

Synonyms:5'-O-(4,4'-dimethoxytrityl)thymidylyl-(3'-5'-carbamoyl)-5'-amino-2'-O,5'-N-cyclo-5'-deoxyarabinouridine

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Chemical Property of 5'-O-(4,4'-dimethoxytrityl)thymidylyl-(3'-5'-carbamoyl)-5'-amino-2'-O,5'-N-cyclo-5'-deoxyarabinouridine

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Technology Process of 5'-O-(4,4'-dimethoxytrityl)thymidylyl-(3'-5'-carbamoyl)-5'-amino-2'-O,5'-N-cyclo-5'-deoxyarabinouridine

There total 1 articles about 5'-O-(4,4'-dimethoxytrityl)thymidylyl-(3'-5'-carbamoyl)-5'-amino-2'-O,5'-N-cyclo-5'-deoxyarabinouridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1138083-44-9
5'-O-(4,4'-dimethoxytrityl)thymidylyl-(3'-5'-carbamoyl)-5'-amino-3'-O-tert-butyldiphenylsilyl-2'-O,5'-N-cyclo-5'-deoxyarabinouridine

: 1080623-55-7
5'-O-(4,4'-dimethoxytrityl)thymidylyl-(3'-5'-carbamoyl)-5'-amino-2'-O,5'-N-cyclo-5'-deoxyarabinouridine

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 0.25h; Inert atmosphere;
DOI:10.1016/j.tet.2008.12.073

Reference yield: 78.0%

: 1080623-55-7
5'-O-(4,4'-dimethoxytrityl)thymidylyl-(3'-5'-carbamoyl)-5'-amino-2'-O,5'-N-cyclo-5'-deoxyarabinouridine

: 102691-36-1
N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite

: 1080623-56-8
5'-O-(4,4'-dimethoxytrityl)thymidylyl-(3'-5'-carbamoyl)-5'-amino-2'-O,5'-N-cyclo-5'-deoxy-3'-O-(N,N-diisopropylamino-β-cyanoethoxyphosphino)arabinouridine

Guidance literature:: With N,N-diisopropylamine tetrazolide; In tetrahydrofuran; acetonitrile; at 20 ℃; Inert atmosphere;
DOI:10.1016/j.tet.2008.12.073