6-bromo-2-(2-hydroxyphenyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione

Base Information

• Chemical Name: 6-bromo-2-(2-hydroxyphenyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione
• CAS No.: 387365-32-4
• Molecular Formula: C₁₈H₁₀BrNO₃
• Molecular Weight: 368.186
• Mol file: 387365-32-4.mol

Synonyms:6-bromo-2-(2-hydroxyphenyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione

Chemical Property of 6-bromo-2-(2-hydroxyphenyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 6-bromo-2-(2-hydroxyphenyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione

There total 1 articles about 6-bromo-2-(2-hydroxyphenyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

4-bromo-1,8-naphthalenedicarboxylic anhydride (81-86-7) + 2-amino-phenol (95-55-6) → 6-bromo-2-(2-hydroxyphenyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione (387365-32-4)

Guidance literature:

In 2-methoxy-ethanol; for 12h; Inert atmosphere; Reflux;

DOI:10.1039/c3nj01389h

Reference yield: 88.6%

4-(carbazol-9-yl)phenylboronic acid (419536-33-7) + 6-bromo-2-(2-hydroxyphenyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione (387365-32-4) → C36H22N2O3

Guidance literature:

4-(carbazol-9-yl)phenylboronic acid; 6-bromo-2-(2-hydroxyphenyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione; With potassium carbonate; In water; N,N-dimethyl-formamide; for 0.25h;

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; N,N-dimethyl-formamide; at 80 ℃; for 15h; Inert atmosphere;

DOI:10.1016/j.tet.2021.131923

Reference yield: 85.0%

6-bromo-2-(2-hydroxyphenyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione (387365-32-4) + sodium methylate (124-41-4) → 2-(2-hydroxyphenyl)-6-methoxy-1H-benzo[de]isoquinoline-1,3(2H)dione (1571072-51-9)

Guidance literature:

With copper(I) bromide; In methanol; for 8h; Inert atmosphere; Reflux;

DOI:10.1039/c3nj01389h

upstream raw materials:

4-bromo-1,8-naphthalenedicarboxylic anhydride

2-amino-phenol

Downstream raw materials:

2-(2-hydroxyphenyl)-6-methoxy-1H-benzo[de]isoquinoline-1,3(2H)dione

6-methoxy-2-(2-(trimethylsilyloxy)phenyl)-1H-benzo[de]isoquinoline-1,3(2H)dione