N-[2-(diethylamino)ethyl]-5-formyl-4-(2-methoxyphenyl)-2-methyl-1H-pyrrole-3-carboxamide

Base Information

Chemical Name:N-[2-(diethylamino)ethyl]-5-formyl-4-(2-methoxyphenyl)-2-methyl-1H-pyrrole-3-carboxamide
CAS No.:1089146-40-6
Molecular Formula:C₂₀H₂₇N₃O₃
Molecular Weight:357.453
Hs Code.:

Synonyms:N-[2-(diethylamino)ethyl]-5-formyl-4-(2-methoxyphenyl)-2-methyl-1H-pyrrole-3-carboxamide

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Chemical Property of N-[2-(diethylamino)ethyl]-5-formyl-4-(2-methoxyphenyl)-2-methyl-1H-pyrrole-3-carboxamide

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Technology Process of N-[2-(diethylamino)ethyl]-5-formyl-4-(2-methoxyphenyl)-2-methyl-1H-pyrrole-3-carboxamide

There total 7 articles about N-[2-(diethylamino)ethyl]-5-formyl-4-(2-methoxyphenyl)-2-methyl-1H-pyrrole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5-formyl-4-(2-methoxyphenyl)-2-methyl-1H-pyrrole-3-carboxylic acid

: 100-36-7
N,N-diethylethylenediamine

: 1089146-40-6
N-[2-(diethylamino)ethyl]-5-formyl-4-(2-methoxyphenyl)-2-methyl-1H-pyrrole-3-carboxamide

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In dichloromethane; at 20 ℃; for 1.5h;

Reference yield:

: 31949-21-0
bromomethyl 2-methoxyphenyl ketone

: 1089146-40-6
N-[2-(diethylamino)ethyl]-5-formyl-4-(2-methoxyphenyl)-2-methyl-1H-pyrrole-3-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: diethyl ether / 20 °C

2.1: hydrogenchloride / ethanol; water / 48 h / 20 °C

3.1: sodium acetate / water / 2 h / 80 °C

4.1: trichlorophosphate / dichloromethane / 20 °C

4.2: 1 h / Heating / reflux

4.3: 24 h / 20 °C

5.1: sodium hydroxide; water / ethanol / 9 h / 80 °C

5.2: 20 °C

6.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / dichloromethane / 1.5 h / 20 °C

With hydrogenchloride; sodium hydroxide; water; sodium acetate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; trichlorophosphate; In diethyl ether; ethanol; dichloromethane; water;

Reference yield:

: ethyl 5-formyl-4-(2-methoxyphenyl)-2-methyl-1H-pyrrole-3-carboxylate

: 1089146-40-6
N-[2-(diethylamino)ethyl]-5-formyl-4-(2-methoxyphenyl)-2-methyl-1H-pyrrole-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide; water / ethanol / 9 h / 80 °C

1.2: 20 °C

2.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / dichloromethane / 1.5 h / 20 °C

With sodium hydroxide; water; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In ethanol; dichloromethane;