(4'S)-1-methyl-1-{2'-[2''-(di-ortho-tolylphosphanyl)-phenyl]-4',5'-dihydrooxazol-4'-yl}-ethyl pivalate

Base Information

Chemical Name:(4'S)-1-methyl-1-{2'-[2''-(di-ortho-tolylphosphanyl)-phenyl]-4',5'-dihydrooxazol-4'-yl}-ethyl pivalate
CAS No.:1313491-71-2
Molecular Formula:C₃₁H₃₆NO₃P
Molecular Weight:501.606
Hs Code.:

Synonyms:(4'S)-1-methyl-1-{2'-[2''-(di-ortho-tolylphosphanyl)-phenyl]-4',5'-dihydrooxazol-4'-yl}-ethyl pivalate

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Chemical Property of (4'S)-1-methyl-1-{2'-[2''-(di-ortho-tolylphosphanyl)-phenyl]-4',5'-dihydrooxazol-4'-yl}-ethyl pivalate

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Technology Process of (4'S)-1-methyl-1-{2'-[2''-(di-ortho-tolylphosphanyl)-phenyl]-4',5'-dihydrooxazol-4'-yl}-ethyl pivalate

There total 7 articles about (4'S)-1-methyl-1-{2'-[2''-(di-ortho-tolylphosphanyl)-phenyl]-4',5'-dihydrooxazol-4'-yl}-ethyl pivalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1313491-65-4
(4'S)-2-{2'-[2''-(di-ortho-tolylphosphanyl)-phenyl]-4',5'-dihydrooxazol-4'-yl}-propan-2-ol

: 3282-30-2
pivaloyl chloride

: 1313491-71-2
(4'S)-1-methyl-1-{2'-[2''-(di-ortho-tolylphosphanyl)-phenyl]-4',5'-dihydrooxazol-4'-yl}-ethyl pivalate

Guidance literature:: (4'S)-2-{2'-[2''-(di-ortho-tolylphosphanyl)-phenyl]-4',5'-dihydrooxazol-4'-yl}-propan-2-ol; With potassium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 2h;

pivaloyl chloride; In tetrahydrofuran; at 0 - 20 ℃; for 22h;
DOI:10.1016/j.tet.2011.02.021

Reference yield:

: 29949-64-2
di(o-tolyl)phosphine

: 1313491-71-2
(4'S)-1-methyl-1-{2'-[2''-(di-ortho-tolylphosphanyl)-phenyl]-4',5'-dihydrooxazol-4'-yl}-ethyl pivalate

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 2.5 h / -78 - 0 °C

2.1: potassium hydride / tetrahydrofuran / 2 h / 0 - 20 °C

2.2: 22 h / 0 - 20 °C

With n-butyllithium; potassium hydride; In tetrahydrofuran; hexane;
DOI:10.1016/j.tet.2011.02.021

Reference yield:

: 393-52-2
2-Fluorobenzoyl chloride

: 1313491-71-2
(4'S)-1-methyl-1-{2'-[2''-(di-ortho-tolylphosphanyl)-phenyl]-4',5'-dihydrooxazol-4'-yl}-ethyl pivalate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / methanol / 2.5 h / 0 °C

2.1: tetrahydrofuran; diethyl ether / 18 h / 0 - 20 °C

2.2: 0 °C / Saturated solution

3.1: triethylamine; p-toluenesulfonyl chloride / dichloromethane / 75 h / 20 °C

4.1: n-butyllithium / tetrahydrofuran; hexane / 2.5 h / -78 - 0 °C

5.1: potassium hydride / tetrahydrofuran / 2 h / 0 - 20 °C

5.2: 22 h / 0 - 20 °C

With n-butyllithium; potassium hydride; triethylamine; p-toluenesulfonyl chloride; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane;
DOI:10.1016/j.tet.2011.02.021