C₁₆H₁₇NO₃

Base Information

• Chemical Name: C₁₆H₁₇NO₃
• CAS No.: 1432505-29-7
• Molecular Formula: C₁₆H₁₇NO₃
• Molecular Weight: 271.316
• Mol file: 1432505-29-7.mol

Synonyms:C₁₆H₁₇NO₃

Chemical Property of C₁₆H₁₇NO₃

Chemical Property:

Purity/Quality:

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• Pictogram(s):  
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Technology Process of C₁₆H₁₇NO₃

There total 1 articles about C₁₆H₁₇NO₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

2,3-dihydro-1-(phenylmethyl)-4(1H)-pyridinone (35487-98-0) + allyl cyanoformate (63934-48-5) → C16H17NO3 (1432505-29-7)

Guidance literature:

2,3-dihydro-1-(phenylmethyl)-4(1H)-pyridinone; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere; Schlenk technique;

allyl cyanoformate; In tetrahydrofuran; at -78 - 23 ℃; for 3h; Schlenk technique; Inert atmosphere;

DOI:10.1002/chem.201300030

Reference yield: 86.0%

C16H17NO3 (1432505-29-7) + methyl iodide (74-88-4) → C17H19NO3 (1432505-59-3)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.5h; Inert atmosphere;

DOI:10.1002/chem.201300030

Reference yield:

C16H17NO3 (1432505-29-7) → C16H19NO (1432505-63-9) + C16H19NO

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; (S)-2-(2-(bis(4-trifluoromethyl-phenyl)-phosphino))-5-(4-trifluoromethyl-phenyl)-4-tert-butyl-4,5-dihydro-oxazole / toluene / 40 °C / Inert atmosphere; Sealed tube

With (S)-2-(2-(bis(4-trifluoromethyl-phenyl)-phosphino))-5-(4-trifluoromethyl-phenyl)-4-tert-butyl-4,5-dihydro-oxazole; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium hydride; In tetrahydrofuran; toluene;

DOI:10.1002/chem.201300030

upstream raw materials:

2,3-dihydro-1-(phenylmethyl)-4(1H)-pyridinone

allyl cyanoformate

Downstream raw materials:

C₁₇H₁₉NO₃

C₁₆H₁₉NO