2-(2-bromo-5-methoxyphenyl)-N-(2-piperidinobenzyl)acetamide

Base Information

• Chemical Name: 2-(2-bromo-5-methoxyphenyl)-N-(2-piperidinobenzyl)acetamide
• CAS No.: 700359-69-9
• Molecular Formula: C₂₁H₂₅BrN₂O₂
• Molecular Weight: 417.346
• Mol file: 700359-69-9.mol

Synonyms:2-(2-bromo-5-methoxyphenyl)-N-(2-piperidinobenzyl)acetamide

Chemical Property of 2-(2-bromo-5-methoxyphenyl)-N-(2-piperidinobenzyl)acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-bromo-5-methoxyphenyl)-N-(2-piperidinobenzyl)acetamide

There total 2 articles about 2-(2-bromo-5-methoxyphenyl)-N-(2-piperidinobenzyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

(2-(piperidin-1-yl)phenyl)methanamine (72752-54-6) + 2-(2-bromo-5-methoxyphenyl)acetic acid (86826-93-9) → 2-(2-bromo-5-methoxyphenyl)-N-(2-piperidinobenzyl)acetamide (700359-69-9)

Guidance literature:

With dicyclohexyl-carbodiimide; In toluene; at 20 ℃; for 10h;

DOI:10.1081/SCC-120028635

Reference yield:

m-methoxyphenylacetic acid (1798-09-0) → 2-(2-bromo-5-methoxyphenyl)-N-(2-piperidinobenzyl)acetamide (700359-69-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / bromine / CH₂Cl₂ / 2 h / 20 °C

2: 62 percent / dicyclohexylcarbodiimide / toluene / 10 h / 20 °C

With bromine; dicyclohexyl-carbodiimide; In dichloromethane; toluene;

DOI:10.1081/SCC-120028635

Reference yield:

2-(2-bromo-5-methoxyphenyl)-N-(2-piperidinobenzyl)acetamide (700359-69-9) → 2-(4-aminosulfonyl-3-methoxyphenyl)-N-(2-piperidinobenzyl)acetamide (700359-73-5)

Guidance literature:

Multi-step reaction with 3 steps

1: chlorosulfonic acid / CH₂Cl₂ / 5 h / Heating

2: NH₃ gas / CH₂Cl₂ / 0 °C

3: 95 percent / ammonium formate / Pd/C / methanol / 4 h / Heating

With chlorosulfonic acid; ammonia; ammonium formate; palladium on activated charcoal; In methanol; dichloromethane;

DOI:10.1081/SCC-120028635

upstream raw materials:

(2-(piperidin-1-yl)phenyl)methanamine

2-(2-bromo-5-methoxyphenyl)acetic acid

m-methoxyphenylacetic acid

Downstream raw materials:

2-(4-aminosulfonyl-3-methoxyphenyl)-N-(2-piperidinobenzyl)acetamide

2-(4-aminosulfonyl-2-bromo-5-methoxyphenyl)-N-(2-piperidinobenzyl)acetamide