N-[2-[3-benzoyl-4-[(4-methylphenyl)acetylamino]phenyl]]-N^α-tert-butyloxycarbonylglycine amide

Base Information

• Chemical Name: N-[2-[3-benzoyl-4-[(4-methylphenyl)acetylamino]phenyl]]-N^α-tert-butyloxycarbonylglycine amide
• CAS No.: 343305-88-4
• Molecular Formula: C₂₉H₃₁N₃O₅
• Molecular Weight: 501.582

Synonyms:N-[2-[3-benzoyl-4-[(4-methylphenyl)acetylamino]phenyl]]-N^α-tert-butyloxycarbonylglycine amide

Chemical Property of N-[2-[3-benzoyl-4-[(4-methylphenyl)acetylamino]phenyl]]-N^α-tert-butyloxycarbonylglycine amide

Chemical Property:

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Technology Process of N-[2-[3-benzoyl-4-[(4-methylphenyl)acetylamino]phenyl]]-N^α-tert-butyloxycarbonylglycine amide

There total 3 articles about N-[2-[3-benzoyl-4-[(4-methylphenyl)acetylamino]phenyl]]-N^α-tert-butyloxycarbonylglycine amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

BOC-glycine (4530-20-5) + N-(4-amino-2-benzoylphenyl)-2-(4-methylphenyl)acetic acid amide (265648-28-0) → N-[2-[3-benzoyl-4-[(4-methylphenyl)acetylamino]phenyl]]-Nα-tert-butyloxycarbonylglycine amide (343305-88-4)

Guidance literature:

BOC-glycine; With 4-methyl-morpholine; isobutyl chloroformate; In N,N-dimethyl-formamide; at -15 ℃; for 0.0833333h;

N-(4-amino-2-benzoylphenyl)-2-(4-methylphenyl)acetic acid amide; In N,N-dimethyl-formamide; at -15 - 20 ℃;

DOI:10.1002/ardp.200300758

Reference yield:

BOC-glycine (4530-20-5) → N-[2-[3-benzoyl-4-[(4-methylphenyl)acetylamino]phenyl]]-Nα-tert-butyloxycarbonylglycine amide (343305-88-4)

Guidance literature:

Multi-step reaction with 2 steps

1: N-methylmorpholine / dimethylformamide / 0.08 h / -15 °C

2: 1.2 g / dimethylformamide / -15 - 20 °C

With 4-methyl-morpholine; In N,N-dimethyl-formamide;

DOI:10.1016/S0968-0896(01)00312-1

Reference yield:

N-(t-butoxycarbonyl)glycyl i-butyl carbonate (66866-43-1) + N-(4-amino-2-benzoylphenyl)-2-(4-methylphenyl)acetic acid amide (265648-28-0) → N-[2-[3-benzoyl-4-[(4-methylphenyl)acetylamino]phenyl]]-Nα-tert-butyloxycarbonylglycine amide (343305-88-4)

Guidance literature:

In N,N-dimethyl-formamide; at -15 - 20 ℃; for 4h;

DOI:10.1002/1521-4184(200102)334:2<40::AID-ARDP40>3.0.CO;2-W

upstream raw materials:

N-(t-butoxycarbonyl)glycyl i-butyl carbonate

N-(4-amino-2-benzoylphenyl)-2-(4-methylphenyl)acetic acid amide

BOC-glycine

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