2-AMINO-3-MORPHOLIN-4-YLPYRAZINE

Base Information

• Chemical Name: 2-AMINO-3-MORPHOLIN-4-YLPYRAZINE
• CAS No.: 117719-16-1
• Molecular Formula: C8H12N4O
• Molecular Weight: 180.21
• Hs Code.: 2934999090
• Mol file: 117719-16-1.mol

Synonyms:Pyrazinamine,3-(4-morpholinyl)- (9CI);2-Amino-3-morpholin-4-ylpyrazine;3-Morpholinopyrazin-2-amine;

Chemical Property of 2-AMINO-3-MORPHOLIN-4-YLPYRAZINE

Chemical Property:

• Refractive Index: 1.601
• Boiling Point: 383.897 °C at 760 mmHg
• Flash Point: 185.975 °C
• PSA: 64.27000
• Density: 1.274 g/cm³
• LogP: 0.54160
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

97% ^*data from raw suppliers

2-Amino-3-morpholin-4-ylpyrazine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AMINO-3-MORPHOLIN-4-YLPYRAZINE

There total 2 articles about 2-AMINO-3-MORPHOLIN-4-YLPYRAZINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

morpholine (110-91-8,99108-56-2) + 3-chloropyrazin-2-amine (6863-73-6) → (3-morpholin-4-ylpyrazin-2-yl)amine (117719-16-1)

Guidance literature:

at 120 ℃; for 12h; Sealed tube;

DOI:10.1016/j.tetlet.2016.04.050

Reference yield: 61.1%

4-{3-[(triphenyl-λ5-phosphanylidene)amino]pyrazin-2-yl}morpholine (1400820-46-3) → (3-morpholin-4-ylpyrazin-2-yl)amine (117719-16-1)

Guidance literature:

With acetic acid; at 85 - 90 ℃;

DOI:10.1016/j.tetlet.2012.07.106

Reference yield: 82.0%

Cyclohexyl isocyanide (931-53-3) + (3-morpholin-4-ylpyrazin-2-yl)amine (117719-16-1) + 4-nitrobenzaldehdye (555-16-8) → N-cyclohexyl-8-morpholino-2-(4-nitrophenyl)imidazo[1,2-a]pyrazin-3-amine (1312550-16-5)

Guidance literature:

With ytterbium(III) triflate; In methanol; at 70 ℃; for 5h;

DOI:10.1039/c4ob01865f

upstream raw materials:

morpholine

3-chloropyrazin-2-amine

4-{3-[(triphenyl-λ⁵-phosphanylidene)amino]pyrazin-2-yl}morpholine