(R)-tertbutyl-7-(3,4-dichlorophenyl)-6-((S)-2-(4-fluorophenyl)pyrrolidine-1-carbonyl)-2,5-dimethylpyrazolo[1,5-a]pyrimidine-4(7H)-carboxylate

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Chemical Name:(R)-tertbutyl-7-(3,4-dichlorophenyl)-6-((S)-2-(4-fluorophenyl)pyrrolidine-1-carbonyl)-2,5-dimethylpyrazolo[1,5-a]pyrimidine-4(7H)-carboxylate
CAS No.:1369959-23-8
Molecular Formula:C₃₀H₃₁Cl₂FN₄O₃
Molecular Weight:585.506
Hs Code.:

Synonyms:(R)-tertbutyl-7-(3,4-dichlorophenyl)-6-((S)-2-(4-fluorophenyl)pyrrolidine-1-carbonyl)-2,5-dimethylpyrazolo[1,5-a]pyrimidine-4(7H)-carboxylate

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Chemical Property of (R)-tertbutyl-7-(3,4-dichlorophenyl)-6-((S)-2-(4-fluorophenyl)pyrrolidine-1-carbonyl)-2,5-dimethylpyrazolo[1,5-a]pyrimidine-4(7H)-carboxylate

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Technology Process of (R)-tertbutyl-7-(3,4-dichlorophenyl)-6-((S)-2-(4-fluorophenyl)pyrrolidine-1-carbonyl)-2,5-dimethylpyrazolo[1,5-a]pyrimidine-4(7H)-carboxylate

There total 4 articles about (R)-tertbutyl-7-(3,4-dichlorophenyl)-6-((S)-2-(4-fluorophenyl)pyrrolidine-1-carbonyl)-2,5-dimethylpyrazolo[1,5-a]pyrimidine-4(7H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 298690-90-1
(S)-2-(4-fluorophenyl)pyrrolidine

: 1369959-01-2
(R)-4-(tert-butoxycarbonyl)-7-(3,4-dichlorophenyl)-2,5-dimethyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-6-carboxylic acid

: 1369959-23-8
(R)-tertbutyl-7-(3,4-dichlorophenyl)-6-((S)-2-(4-fluorophenyl)pyrrolidine-1-carbonyl)-2,5-dimethylpyrazolo[1,5-a]pyrimidine-4(7H)-carboxylate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 14h; Inert atmosphere;
DOI:10.1021/jm201386u

Reference yield:

: 1369959-19-2
methyl 7-(3,4-dichlorophenyl)-2,5-dimethyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-6-carboxylate

: 1369959-23-8
(R)-tertbutyl-7-(3,4-dichlorophenyl)-6-((S)-2-(4-fluorophenyl)pyrrolidine-1-carbonyl)-2,5-dimethylpyrazolo[1,5-a]pyrimidine-4(7H)-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: dmap / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

2.1: Chiral cell AD column / ethanol; n-heptane / Inert atmosphere; Resolution of racemate

3.1: lithium hydroxide / tetrahydrofuran; water / 15 h / 20 °C / Inert atmosphere

3.2: Inert atmosphere

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 14 h / 20 °C / Inert atmosphere

With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In tetrahydrofuran; ethanol; n-heptane; dichloromethane; water;
DOI:10.1021/jm201386u

Reference yield:

: 1369959-20-5
4-tert-butyl-6-methyl-7-(3,4-dichlorophenyl)-2,5-dimethylpyrazolo[1,5-a]pyrimidine-4,6(7H)-dicarboxylate

: 1369959-23-8
(R)-tertbutyl-7-(3,4-dichlorophenyl)-6-((S)-2-(4-fluorophenyl)pyrrolidine-1-carbonyl)-2,5-dimethylpyrazolo[1,5-a]pyrimidine-4(7H)-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: Chiral cell AD column / ethanol; n-heptane / Inert atmosphere; Resolution of racemate

2.1: lithium hydroxide / tetrahydrofuran; water / 15 h / 20 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 14 h / 20 °C / Inert atmosphere

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In tetrahydrofuran; ethanol; n-heptane; dichloromethane; water;
DOI:10.1021/jm201386u