9-Imidazol-1-yl-8-(4-methoxy-benzyloxymethyl)-nonanoic acid ethyl ester

Base Information

Chemical Name:9-Imidazol-1-yl-8-(4-methoxy-benzyloxymethyl)-nonanoic acid ethyl ester
CAS No.:109786-97-2
Molecular Formula:C₂₃H₃₄N₂O₄
Molecular Weight:402.534
Hs Code.:

Synonyms:9-Imidazol-1-yl-8-(4-methoxy-benzyloxymethyl)-nonanoic acid ethyl ester

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Chemical Property of 9-Imidazol-1-yl-8-(4-methoxy-benzyloxymethyl)-nonanoic acid ethyl ester

Chemical Property:

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Technology Process of 9-Imidazol-1-yl-8-(4-methoxy-benzyloxymethyl)-nonanoic acid ethyl ester

There total 8 articles about 9-Imidazol-1-yl-8-(4-methoxy-benzyloxymethyl)-nonanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 84727-35-5
1-[2-hydroxy-3-[(4-methoxyphenyl)methoxy]propyl]-1H-imidazole

: 109786-97-2
9-Imidazol-1-yl-8-(4-methoxy-benzyloxymethyl)-nonanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 92 percent / oxalyl chloride, DMSO / CH₂Cl₂ / 0.25 h / -60 °C

2: 53 percent / tetrahydrofuran / 72 h / 18 °C

3: LiAlH₄ / tetrahydrofuran / 12 h

4: DMSO, oxalyl chloride / CH₂Cl₂ / 0.25 h / -60 °C

5: 1.) KO-t-Bu / 1.) THF, 0 deg C, 30 min, 2.) THF, RT, 16 h

6: 85 percent / H₂ / 10percent Pd/C / ethanol / 2 h / 760 Torr

7: triethylamime / CH₂Cl₂ / 0.5 h / -50 - 0 °C

8: CH₂Cl₂ / 15 h / 18 °C

With lithium aluminium tetrahydride; oxalyl dichloride; potassium tert-butylate; hydrogen; dimethyl sulfoxide; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm00393a022

Reference yield:

: 99500-31-9
1-(1H-imidazol-1-yl)-3-<(4-methoxyphenyl)methoxy>-2-propanone

: 109786-97-2
9-Imidazol-1-yl-8-(4-methoxy-benzyloxymethyl)-nonanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 53 percent / tetrahydrofuran / 72 h / 18 °C

2: LiAlH₄ / tetrahydrofuran / 12 h

3: DMSO, oxalyl chloride / CH₂Cl₂ / 0.25 h / -60 °C

4: 1.) KO-t-Bu / 1.) THF, 0 deg C, 30 min, 2.) THF, RT, 16 h

5: 85 percent / H₂ / 10percent Pd/C / ethanol / 2 h / 760 Torr

6: triethylamime / CH₂Cl₂ / 0.5 h / -50 - 0 °C

7: CH₂Cl₂ / 15 h / 18 °C

With lithium aluminium tetrahydride; oxalyl dichloride; potassium tert-butylate; hydrogen; dimethyl sulfoxide; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm00393a022

Reference yield:

: 109786-84-7
3-Imidazol-1-ylmethyl-4-(4-methoxy-benzyloxy)-butan-1-ol

: 109786-97-2
9-Imidazol-1-yl-8-(4-methoxy-benzyloxymethyl)-nonanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: DMSO, oxalyl chloride / CH₂Cl₂ / 0.25 h / -60 °C

2: 1.) KO-t-Bu / 1.) THF, 0 deg C, 30 min, 2.) THF, RT, 16 h

3: 85 percent / H₂ / 10percent Pd/C / ethanol / 2 h / 760 Torr

4: triethylamime / CH₂Cl₂ / 0.5 h / -50 - 0 °C

5: CH₂Cl₂ / 15 h / 18 °C

With oxalyl dichloride; potassium tert-butylate; hydrogen; dimethyl sulfoxide; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1021/jm00393a022