N-(3-{2-[methyl(methylsulfonyl)amino]phenyl}-11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-7-yl)acetamide

Base Information

Chemical Name:N-(3-{2-[methyl(methylsulfonyl)amino]phenyl}-11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-7-yl)acetamide
CAS No.:1372590-75-4
Molecular Formula:C₂₃H₂₂N₄O₄S
Molecular Weight:450.518
Hs Code.:

Synonyms:N-(3-{2-[methyl(methylsulfonyl)amino]phenyl}-11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-7-yl)acetamide

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Chemical Property of N-(3-{2-[methyl(methylsulfonyl)amino]phenyl}-11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-7-yl)acetamide

Chemical Property:

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Technology Process of N-(3-{2-[methyl(methylsulfonyl)amino]phenyl}-11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-7-yl)acetamide

There total 12 articles about N-(3-{2-[methyl(methylsulfonyl)amino]phenyl}-11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-7-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1372590-71-0
N-[2-(7-amino-11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-3-yl)phenyl]-N-methylmethanesulfonamide

: 75-36-5
acetyl chloride

: 1372590-75-4
N-(3-{2-[methyl(methylsulfonyl)amino]phenyl}-11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-7-yl)acetamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 2-amino-4-(N-tert-butoxycarbonylamino)nitrobenzene

: 1372590-75-4
N-(3-{2-[methyl(methylsulfonyl)amino]phenyl}-11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-7-yl)acetamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: caesium carbonate / palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / toluene / 16 h / 95 °C

2.1: hydrogen / Raney Ni / tetrahydrofuran; methanol / 3 h / 20 °C / 1551.49 Torr

3.1: water; lithium hydroxide / tetrahydrofuran; methanol / 16 h / 60 °C

3.2: 20 °C / pH 6

4.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 96 h / 20 °C

5.1: caesium carbonate / dihydrogen dichloro-bis(di-tert-butylphosphinito-κP)palladium(2-) / N,N-dimethyl-formamide; water / 0.5 h / 150 °C / Microwave irradiation

6.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

7.1: triethylamine / dichloromethane / 2 h / 20 °C

With water; hydrogen; caesium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; trifluoroacetic acid; lithium hydroxide; 1,1'-bis-(diphenylphosphino)ferrocene; dihydrogen dichloro-bis(di-tert-butylphosphinito-κP)palladium(2-); palladium diacetate; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; 1.1: Buchwald-Hartwig amination / 5.1: Suzuki Coupling;

Reference yield:

: 181765-85-5
methyl 2-iodo 4-chlorobenzoate

: 1372590-75-4
N-(3-{2-[methyl(methylsulfonyl)amino]phenyl}-11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-7-yl)acetamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: caesium carbonate / palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / toluene / 16 h / 95 °C

2.1: hydrogen / Raney Ni / tetrahydrofuran; methanol / 3 h / 20 °C / 1551.49 Torr

3.1: water; lithium hydroxide / tetrahydrofuran; methanol / 16 h / 60 °C

3.2: 20 °C / pH 6

4.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 96 h / 20 °C

5.1: caesium carbonate / dihydrogen dichloro-bis(di-tert-butylphosphinito-κP)palladium(2-) / N,N-dimethyl-formamide; water / 0.5 h / 150 °C / Microwave irradiation

6.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

7.1: triethylamine / dichloromethane / 2 h / 20 °C

With water; hydrogen; caesium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; trifluoroacetic acid; lithium hydroxide; 1,1'-bis-(diphenylphosphino)ferrocene; dihydrogen dichloro-bis(di-tert-butylphosphinito-κP)palladium(2-); palladium diacetate; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; 1.1: Buchwald-Hartwig amination / 5.1: Suzuki Coupling;