methyl 1-({[1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)cyclopentanecarboxylate

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Chemical Name:methyl 1-({[1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)cyclopentanecarboxylate
CAS No.:1612148-89-6
Molecular Formula:C₂₈H₂₇ClN₄O₅
Molecular Weight:534.999
Hs Code.:

Synonyms:methyl 1-({[1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)cyclopentanecarboxylate

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Chemical Property of methyl 1-({[1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)cyclopentanecarboxylate

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Technology Process of methyl 1-({[1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)cyclopentanecarboxylate

There total 5 articles about methyl 1-({[1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)cyclopentanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1146757-92-7
1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carboxylic acid

: 60421-23-0
cycloleucine methyl ester hydrochloride

: 1612148-89-6
methyl 1-({[1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)cyclopentanecarboxylate

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In dichloromethane; at 20 ℃; for 16h; Inert atmosphere;
DOI:10.1021/jm5003843

Reference yield: 85.0%

: 1612148-89-6
methyl 1-({[1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)cyclopentanecarboxylate

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In dichloromethane; for 16h; Inert atmosphere;

Reference yield:

: methyl 4-(2,6-dimethoxyphenyl)-2,4-dioxobutanoate sodium salt

: 1612148-89-6
methyl 1-({[1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)cyclopentanecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid; hydrogenchloride / water / Inert atmosphere; Reflux

2.1: lithium hydroxide / 1,4-dioxane / 16 h / 20 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / dichloromethane / 16 h / 20 °C / Inert atmosphere

With hydrogenchloride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; acetic acid; triethylamine; lithium hydroxide; In 1,4-dioxane; dichloromethane; water; 1.1: |Knorr Pyrazole Synthesis;
DOI:10.1021/jm5003843