N-(3,9,10,11-tetramethoxy-7-oxo-6,7-dihydro-5H-dibenzo [a,c][7]cyclohepten-5-yl)-2,2,2-trifluoroacetamide

Base Information

Chemical Name:N-(3,9,10,11-tetramethoxy-7-oxo-6,7-dihydro-5H-dibenzo [a,c][7]cyclohepten-5-yl)-2,2,2-trifluoroacetamide
CAS No.:1373112-86-7
Molecular Formula:C₂₁H₂₀F₃NO₆
Molecular Weight:439.388
Hs Code.:

Synonyms:N-(3,9,10,11-tetramethoxy-7-oxo-6,7-dihydro-5H-dibenzo [a,c][7]cyclohepten-5-yl)-2,2,2-trifluoroacetamide

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Chemical Property of N-(3,9,10,11-tetramethoxy-7-oxo-6,7-dihydro-5H-dibenzo [a,c][7]cyclohepten-5-yl)-2,2,2-trifluoroacetamide

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Technology Process of N-(3,9,10,11-tetramethoxy-7-oxo-6,7-dihydro-5H-dibenzo [a,c][7]cyclohepten-5-yl)-2,2,2-trifluoroacetamide

There total 4 articles about N-(3,9,10,11-tetramethoxy-7-oxo-6,7-dihydro-5H-dibenzo [a,c][7]cyclohepten-5-yl)-2,2,2-trifluoroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 1373112-93-6
3-amino-3-(2',3',4,4'-tetramethoxybiphenyl-2-yl)propanoic acid hydrochloride

: 407-25-0
trifluoroacetic anhydride

: 1373112-76-5
N-[4-methoxy-3-oxo-7-(2,3,4-trimethoxyphenyl)-2,3-dihydro-1H-inden-1-yl]-2,2,2-trifluoroacetamide

: 1373112-86-7
N-(3,9,10,11-tetramethoxy-7-oxo-6,7-dihydro-5H-dibenzo [a,c][7]cyclohepten-5-yl)-2,2,2-trifluoroacetamide

Guidance literature:: 3-amino-3-(2',3',4,4'-tetramethoxybiphenyl-2-yl)propanoic acid hydrochloride; With trifluoroacetic acid; at 20 ℃; for 1h;

trifluoroacetic anhydride; for 3h; Reflux;
DOI:10.1016/j.bmc.2012.02.043

Reference yield:

: 7507-86-0
2-bromo-5-methoxy-benzaldehyde

: 1373112-76-5
N-[4-methoxy-3-oxo-7-(2,3,4-trimethoxyphenyl)-2,3-dihydro-1H-inden-1-yl]-2,2,2-trifluoroacetamide

: 1373112-86-7
N-(3,9,10,11-tetramethoxy-7-oxo-6,7-dihydro-5H-dibenzo [a,c][7]cyclohepten-5-yl)-2,2,2-trifluoroacetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium phosphate monohydrate / 1,2-dimethoxyethane / 1.5 h / 150 °C / Microwave irradiation

2.1: ammonium acetate / ethanol / 20 h / Reflux

3.1: trifluoroacetic acid / 1 h / 20 °C

3.2: 3 h / Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium phosphate monohydrate; ammonium acetate; trifluoroacetic acid; In 1,2-dimethoxyethane; ethanol; 1.1: Suzuki-Miyaura cross-coupling / 2.1: Rodionov-Johnson reaction;
DOI:10.1016/j.bmc.2012.02.043

Reference yield:

: 118062-05-8
2,3,4-trimethoxyphenylboronic acid

: 1373112-76-5
N-[4-methoxy-3-oxo-7-(2,3,4-trimethoxyphenyl)-2,3-dihydro-1H-inden-1-yl]-2,2,2-trifluoroacetamide

: 1373112-86-7
N-(3,9,10,11-tetramethoxy-7-oxo-6,7-dihydro-5H-dibenzo [a,c][7]cyclohepten-5-yl)-2,2,2-trifluoroacetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium phosphate monohydrate / 1,2-dimethoxyethane / 1.5 h / 150 °C / Microwave irradiation

2.1: ammonium acetate / ethanol / 20 h / Reflux

3.1: trifluoroacetic acid / 1 h / 20 °C

3.2: 3 h / Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium phosphate monohydrate; ammonium acetate; trifluoroacetic acid; In 1,2-dimethoxyethane; ethanol; 1.1: Suzuki-Miyaura cross-coupling / 2.1: Rodionov-Johnson reaction;
DOI:10.1016/j.bmc.2012.02.043