C₄₁H₆₇NO₇S₂Si

Base Information

• Chemical Name: C₄₁H₆₇NO₇S₂Si
• CAS No.: 1300655-96-2
• Molecular Formula: C₄₁H₆₇NO₇S₂Si
• Molecular Weight: 778.203
• Mol file: 1300655-96-2.mol

Synonyms:C₄₁H₆₇NO₇S₂Si

Chemical Property of C₄₁H₆₇NO₇S₂Si

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₁H₆₇NO₇S₂Si

There total 15 articles about C₄₁H₆₇NO₇S₂Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

C34H56O8Si (1300655-95-1) + (R)-1-(4-isopropyl-2-thioxothiazolidin-3-yl)propan-1-one (487029-68-5) → C41H67NO7S2Si (1300655-96-2)

Guidance literature:

(R)-1-(4-isopropyl-2-thioxothiazolidin-3-yl)propan-1-one; With titanium tetrachloride; In dichloromethane; at 0 ℃; for 0.0833333h; Inert atmosphere;

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at -40 ℃; for 3h; Inert atmosphere;

C₃₄H₅₆O₈Si; diastereoselective reaction; Further stages;

DOI:10.1021/ja201467z

Reference yield:

C13H18O2 (1300655-86-0) → C41H67NO7S2Si (1300655-96-2)

Guidance literature:

Multi-step reaction with 12 steps

1.1: n-butyllithium / hexane; tert-butyl methyl ether / 0.17 h / -78 °C / Inert atmosphere

1.2: 0.67 h / 0 - 20 °C / Inert atmosphere

2.1: sodium hydride / hexane / 2 h / Inert atmosphere; Reflux

3.1: acetylacetonatodicarbonylrhodium(l) / benzene / 4.5 h / 60 °C / 51716.2 Torr / Autoclave

3.2: 1 h / 40 °C / Inert atmosphere

4.1: 2,6-dimethylpyridine / dichloromethane / 1 h / -78 °C / Inert atmosphere

5.1: diisobutylaluminium hydride / tetrahydrofuran; hexane / -78 °C / Inert atmosphere

5.2: -78 - 20 °C / Inert atmosphere

6.1: toluene / 18 h / Inert atmosphere; Reflux

7.1: osmium(VIII) oxide; water; 4-methylmorpholine N-oxide; citric acid / tetrahydrofuran; tert-butyl alcohol / 24 h / Inert atmosphere

8.1: sodium periodate; sodium hydrogencarbonate / tetrahydrofuran; water / 1 h / 0 °C / Inert atmosphere

9.1: tetra-(n-butyl)ammonium iodide / dichloromethane; water / 3 h / Inert atmosphere

10.1: acetylacetonatodicarbonylrhodium(l); hydrogen; triphenylphosphine / tetrahydrofuran / 24 h / 20 - 50 °C / 25858.1 Torr / Autoclave

11.1: pyridine; dmap / dichloromethane / 16 h / -20 °C / Inert atmosphere

12.1: titanium tetrachloride / dichloromethane / 0.08 h / 0 °C / Inert atmosphere

12.2: 3 h / -40 °C / Inert atmosphere

With pyridine; 2,6-dimethylpyridine; dmap; acetylacetonatodicarbonylrhodium(l); sodium periodate; osmium(VIII) oxide; n-butyllithium; water; hydrogen; titanium tetrachloride; tetra-(n-butyl)ammonium iodide; sodium hydride; diisobutylaluminium hydride; sodium hydrogencarbonate; 4-methylmorpholine N-oxide; triphenylphosphine; citric acid; In tetrahydrofuran; hexane; dichloromethane; tert-butyl methyl ether; water; toluene; tert-butyl alcohol; benzene; 9.1: Felkin addition;

DOI:10.1021/ja201467z

Reference yield:

C31H52O6Si (1300655-94-0) → C41H67NO7S2Si (1300655-96-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: acetylacetonatodicarbonylrhodium(l); hydrogen; triphenylphosphine / tetrahydrofuran / 24 h / 20 - 50 °C / 25858.1 Torr / Autoclave

2.1: pyridine; dmap / dichloromethane / 16 h / -20 °C / Inert atmosphere

3.1: titanium tetrachloride / dichloromethane / 0.08 h / 0 °C / Inert atmosphere

3.2: 3 h / -40 °C / Inert atmosphere

With pyridine; dmap; acetylacetonatodicarbonylrhodium(l); hydrogen; titanium tetrachloride; triphenylphosphine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/ja201467z

upstream raw materials:

C₁₃H₁₈O₂

C₃₁H₅₂O₆Si

C₃₄H₅₆O₈Si

(R)-1-(4-isopropyl-2-thioxothiazolidin-3-yl)propan-1-one

Downstream raw materials:

C₃₆H₅₈N₄O₇SSi

C₃₆H₅₈N₄O₉SSi

C₄₉H₈₂O₉Si