6393-17-5

Basic information

• Product Name: N-(4-iodophenyl)formamide
• CAS NO: 6393-17-5
• Molecular Formula: C₇H₆INO
• Molecular Weight: 247.0331
• Mol File: 6393-17-5.mol
• Article Data: 35

Chemical Properties

• Boiling Point: 351.6°C at 760 mmHg
• Flash Point: 166.5°C
• Density: 1.925g/cm³
• Vapor Pressure: 4.06E-05mmHg at 25°C
• Refractive Index: 1.688
• CAS DataBase Reference: N-(4-iodophenyl)formamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-iodophenyl)formamide(6393-17-5)
• EPA Substance Registry System: N-(4-iodophenyl)formamide(6393-17-5)

Safety Data

• Hazardous Substances Data: 6393-17-5(Hazardous Substances Data)

Upstream product

• 540-37-4 p-aminoiodobenzene 
• 109-94-4 formic acid ethyl ester 
• 698-70-4 4-Iodo-N,N-dimethylaniline 
• 636-98-6 p-nitrobenzene iodide 
• 16712-16-6 ammonium formate 
• 1711-02-0 4-iodobenzoic acid chloride 
• 298-12-4 Glyoxilic acid 
• 68-12-2 N,N-dimethyl-formamide 
• 77287-34-4 formamide 
• 124-38-9 carbon dioxide 
• 64-18-6 formic acid 
• 149-73-5 trimethyl orthoformate 
• 66-25-1 hexanal 
• 50-00-0 formaldehyd 

Downstream Products

• 60577-34-6 p-iodo-N-methylaniline 
• 546112-67-8 N-{4-[4-(4-formylaminophenylethynyl)-2-nitrophenylethynyl]phenyl}formamide 
• 546112-64-5 N-{4-[3-nitro-4-(phenylethynyl)phenylethynyl]phenyl}formamide 
• 556067-78-8 N-{4-[4-(4-formylamino-phenylethynyl)-3,2'-dinitro-biphenylethynyl]-phenyl}-formamide 
• 556067-93-7 N-[4-(2'-dinitro-4'-phenylethynyl-biphenyl-4-ylethynyl)-phenyl]-formamide 
• 556067-74-4 N-[4-(3,2'-dinitro-4'-phenylethynyl-biphenyl-4-ylethynyl)-phenyl]-formamide 
• 556068-03-2 N-[4-(5-nitro-7-phenylethynyl-9H-fluoren-2-ylethynyl)-phenyl]-formamide 
• 1029111-34-9 ethyl 4-[4'-(formylamino)-1,1'-biphenyl-4-yl]-4-oxo-2-(2-phenylethyl)butanoate 
• 66885-67-4 para-iodophenyl isocyanate 
• 352020-08-7 N-(4-iodophenyl)cyanamide 

Relevant articles and documents

Thio- and selenosemicarbazones as antiprotozoal agents against Trypanosoma cruzi and Trichomonas vaginalis

Herein, we report the preparation of a panel of Schiff bases analogues as antiprotozoal agents by modification of the stereoelectronic effects of the substituents on N-1 and N-4 and the nature of the chalcogen atom (S, Se). These compounds were evaluated towards Trypanosoma cruzi and Trichomonas vaginalis. Thiosemicarbazide 31 showed the best trypanocidal profile (epimastigotes), similar to benznidazole (BZ): IC50 (31)=28.72 μM (CL-B5 strain) and 33.65 μM (Y strain), IC50 (BZ)=25.31 μM (CL-B5) and 22.73 μM (Y); it lacked toxicity over mammalian cells (CC50 > 256 μM). Thiosemicarbazones 49, 51 and 63 showed remarkable trichomonacidal effects (IC50?=16.39, 14.84 and 14.89 μM) and no unspecific cytotoxicity towards Vero cells (CC50 ≥ 275 μM). Selenoisosters 74 and 75 presented a slightly enhanced activity (IC50=11.10 and 11.02 μM, respectively). Hydrogenosome membrane potential and structural changes were analysed to get more insight into the trichomonacidal mechanism.

Copper-Catalyzed Cascade N-Dealkylation/N-Methyl Oxidation of Aromatic Amines by Using TEMPO and Oxygen as Oxidants

A novel tandem N-dealkylation and N-methyl aerobic oxidation of tertiary aromatic amines to N-arylformamides using copper and TEMPO has been developed. This methodology suggested an alternative synthetic route from N-methylarylamines to N-arylformamides.

Borane-Trimethylamine Complex as a Reducing Agent for Selective Methylation and Formylation of Amines with CO2

We report herein that a borane-trimethylamine complex worked as an efficient reducing agent for the selective methylation and formylation of amines with 1 atm CO2 under metal-free conditions. 6-Amino-2-picoline serves as a highly efficient catalyst for the methylation of various secondary amines, whereas in its absence, the formylation of primary and secondary amines was achieved in high yield with high chemoselectivity. Mechanistic studies suggest that the 6-amino-2-picoline-borane catalytic system operates like an intramolecular frustrated Lewis pair to activate CO2.