(R)-5-methoxychroman-3-amine

Base Information

Chemical Name:(R)-5-methoxychroman-3-amine
CAS No.:117444-30-1
Molecular Formula:C10H13 N O2
Molecular Weight:179.219
Hs Code.:2932999099
DSSTox Substance ID:DTXSID00445659
Nikkaji Number:J1.624.345K
Wikidata:Q82264164
Mol file:117444-30-1.mol

Synonyms:117444-30-1;(3R)-3,4-Dihydro-5-methoxy-2H-1-Benzopyran-3-amine;(R)-5-methoxychroman-3-amine;(3R)-5-methoxy-3,4-dihydro-2H-chromen-3-amine;(R)-3-Amino-5-methoxychroman;(3R)-5-Methoxy-3,4-dihydro-2H-1-benzopyran-3-amine;(3R)-5-methoxychroman-3-amine;SCHEMBL4839911;DTXSID00445659;UHODZRKJYJILTL-SSDOTTSWSA-N;AKOS006324500;A18107;(3R)-[5-methoxy-3,4-dihydro-2H-chromen-3-yl]amine

Suppliers and Price of (R)-5-methoxychroman-3-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 13 raw suppliers

Chemical Property of (R)-5-methoxychroman-3-amine

Chemical Property:

Vapor Pressure:0.001mmHg at 25°C
Refractive Index:1.545
Boiling Point:308.692°C at 760 mmHg
Flash Point:153.316°C
PSA：44.48000
Density:1.128g/cm³
LogP:1.65770
XLogP3:1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:179.094628657
Heavy Atom Count:13
Complexity:174

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=CC2=C1CC(CO2)N
Isomeric SMILES:COC1=CC=CC2=C1C[C@H](CO2)N

Technology Process of (R)-5-methoxychroman-3-amine

There total 2 articles about (R)-5-methoxychroman-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 57234-28-3
1-methoxy-3-(methoxymethoxy)benzene

: 117444-30-1
(R)-3-Amino-5-methoxy-3,4-dihydro-2H-1-benzopyran

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-BuLi / diethyl ether; hexane / 2 h / Heating

1.2: 70 percent / diethyl ether / 0.25 h / Heating

2.1: 66 percent / tetrahydrofuran / 26 h / Heating

3.1: 60 percent / Bu₃SnH; AIBN / toluene / 18 h / Heating

4.1: 64 percent / TMSBr / CH₂Cl₂ / 2 h / -30 °C

5.1: 74 percent / Ph₃P; DEAD / toluene / 1 h / 80 °C

6.1: 78 percent / TFA / CH₂Cl₂ / 9 h / 20 °C

With n-butyllithium; 2,2'-azobis(isobutyronitrile); trimethylsilyl bromide; tri-n-butyl-tin hydride; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; toluene;
DOI:10.1016/S0957-4166(01)00202-6