trans-1-(4-chloro-3-trifluoromethylphenyl)-3-[4-(4-cyanophenoxy)cyclohexyl]urea

Base Information

Chemical Name:trans-1-(4-chloro-3-trifluoromethylphenyl)-3-[4-(4-cyanophenoxy)cyclohexyl]urea
CAS No.:1394011-86-9
Molecular Formula:C₂₁H₁₉ClF₃N₃O₂
Molecular Weight:437.849
Hs Code.:

Synonyms:trans-1-(4-chloro-3-trifluoromethylphenyl)-3-[4-(4-cyanophenoxy)cyclohexyl]urea

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Chemical Property of trans-1-(4-chloro-3-trifluoromethylphenyl)-3-[4-(4-cyanophenoxy)cyclohexyl]urea

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Technology Process of trans-1-(4-chloro-3-trifluoromethylphenyl)-3-[4-(4-cyanophenoxy)cyclohexyl]urea

There total 3 articles about trans-1-(4-chloro-3-trifluoromethylphenyl)-3-[4-(4-cyanophenoxy)cyclohexyl]urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1194-02-1,143234-87-1
4-fluorobenzonitrile

: 1394011-78-9
trans-1-(4-chloro-3-trifluoromethylphenyl)-3-(4-hydroxycyclohexyl)urea

: 1394011-86-9
trans-1-(4-chloro-3-trifluoromethylphenyl)-3-[4-(4-cyanophenoxy)cyclohexyl]urea

Guidance literature:: trans-1-(4-chloro-3-trifluoromethylphenyl)-3-(4-hydroxycyclohexyl)urea; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.166667h; Inert atmosphere;

4-fluorobenzonitrile; In mineral oil; at 0 - 20 ℃; Inert atmosphere;

Reference yield:

: 50910-54-8
trans-4-aminocyclohexanol hydrochloride

: 1394011-86-9
trans-1-(4-chloro-3-trifluoromethylphenyl)-3-[4-(4-cyanophenoxy)cyclohexyl]urea

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 °C / Inert atmosphere

2.2: 0 - 20 °C / Inert atmosphere

With sodium hydride; triethylamine; In N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 327-78-6
4-chloro-3-(trifluoromethyl)phenyl isocyanate

: 1394011-86-9
trans-1-(4-chloro-3-trifluoromethylphenyl)-3-[4-(4-cyanophenoxy)cyclohexyl]urea

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 °C / Inert atmosphere

2.2: 0 - 20 °C / Inert atmosphere

With sodium hydride; triethylamine; In N,N-dimethyl-formamide; mineral oil;