trans-4-{4-[3-(4-chloro-3-trifluoromethylphenyl)ureido]cyclohexyloxy}benzoic acid

Base Information

Chemical Name:trans-4-{4-[3-(4-chloro-3-trifluoromethylphenyl)ureido]cyclohexyloxy}benzoic acid
CAS No.:1394011-87-0
Molecular Formula:C₂₁H₂₀ClF₃N₂O₄
Molecular Weight:456.849
Hs Code.:

Synonyms:trans-4-{4-[3-(4-chloro-3-trifluoromethylphenyl)ureido]cyclohexyloxy}benzoic acid

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Chemical Property of trans-4-{4-[3-(4-chloro-3-trifluoromethylphenyl)ureido]cyclohexyloxy}benzoic acid

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Technology Process of trans-4-{4-[3-(4-chloro-3-trifluoromethylphenyl)ureido]cyclohexyloxy}benzoic acid

There total 4 articles about trans-4-{4-[3-(4-chloro-3-trifluoromethylphenyl)ureido]cyclohexyloxy}benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1394011-86-9
trans-1-(4-chloro-3-trifluoromethylphenyl)-3-[4-(4-cyanophenoxy)cyclohexyl]urea

: 1394011-87-0
trans-4-{4-[3-(4-chloro-3-trifluoromethylphenyl)ureido]cyclohexyloxy}benzoic acid

Guidance literature:: With ethanol; sodium hydroxide; at 20 - 80 ℃; Inert atmosphere;

Reference yield:

: 50910-54-8
trans-4-aminocyclohexanol hydrochloride

: 1394011-87-0
trans-4-{4-[3-(4-chloro-3-trifluoromethylphenyl)ureido]cyclohexyloxy}benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 °C / Inert atmosphere

2.2: 0 - 20 °C / Inert atmosphere

3.1: sodium hydroxide; ethanol / 20 - 80 °C / Inert atmosphere

With ethanol; sodium hydride; triethylamine; sodium hydroxide; In N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 327-78-6
4-chloro-3-(trifluoromethyl)phenyl isocyanate

: 1394011-87-0
trans-4-{4-[3-(4-chloro-3-trifluoromethylphenyl)ureido]cyclohexyloxy}benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 °C / Inert atmosphere

2.2: 0 - 20 °C / Inert atmosphere

3.1: sodium hydroxide; ethanol / 20 - 80 °C / Inert atmosphere

With ethanol; sodium hydride; triethylamine; sodium hydroxide; In N,N-dimethyl-formamide; mineral oil;