(R)-2-((2R,4R,5R)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)-4-methylpentan-3-one

Base Information

Chemical Name:(R)-2-((2R,4R,5R)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)-4-methylpentan-3-one
CAS No.:957782-29-5
Molecular Formula:C₁₈H₂₆O₄
Molecular Weight:306.402
Hs Code.:

Synonyms:(R)-2-((2R,4R,5R)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)-4-methylpentan-3-one

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Chemical Property of (R)-2-((2R,4R,5R)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)-4-methylpentan-3-one

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Technology Process of (R)-2-((2R,4R,5R)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)-4-methylpentan-3-one

There total 6 articles about (R)-2-((2R,4R,5R)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)-4-methylpentan-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 957782-25-1
(2S,3R)-2-((2R,4R,5R)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)-4-methylpentan-3-ol

: 957782-29-5
(R)-2-((2R,4R,5R)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)-4-methylpentan-3-one

Guidance literature:: With pyridine; Dess-Martin periodane; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1021/jo701524p

Reference yield:

: 957782-23-9
(S)-2-((2R,4S,5R)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)propan-1-ol

: 957782-29-5
(R)-2-((2R,4R,5R)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)-4-methylpentan-3-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: 90 percent / Dess-Martin periodinane; pyridine / CH₂Cl₂ / 3 h / 20 °C

2.1: Mg / tetrahydrofuran / 1 h / 20 °C

2.2: 60 percent / tetrahydrofuran / -78 - 20 °C

3.1: 99 percent / Dess-Martin periodinane; pyridine / CH₂Cl₂ / 3 h / 20 °C

With pyridine; Dess-Martin periodane; magnesium; In tetrahydrofuran; dichloromethane; 1.1: Dess-Martin oxidation / 2.2: Grignard addition / 3.1: Dess-Martin oxidation;
DOI:10.1021/jo701524p

Reference yield:

: 663942-91-4
(2S,3R,4R)-3,5-dihydroxy-2,4-dimethylpentyl acetate

: 957782-29-5
(R)-2-((2R,4R,5R)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)-4-methylpentan-3-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: p-toluenesulfonic acid monohydrate / CH₂Cl₂ / 4 h

2.1: 72.0 mg / KOH; MeOH / CH₂Cl₂ / 20 °C

3.1: 90 percent / Dess-Martin periodinane; pyridine / CH₂Cl₂ / 3 h / 20 °C

4.1: Mg / tetrahydrofuran / 1 h / 20 °C

4.2: 60 percent / tetrahydrofuran / -78 - 20 °C

5.1: 99 percent / Dess-Martin periodinane; pyridine / CH₂Cl₂ / 3 h / 20 °C

With pyridine; methanol; potassium hydroxide; Dess-Martin periodane; toluene-4-sulfonic acid; magnesium; In tetrahydrofuran; dichloromethane; 3.1: Dess-Martin oxidation / 4.2: Grignard addition / 5.1: Dess-Martin oxidation;
DOI:10.1021/jo701524p