Technology Process of Benzoic acid (Z)-(R)-1-((R)-1,2-dihydroxy-ethyl)-non-3-enyl ester
There total 11 articles about Benzoic acid (Z)-(R)-1-((R)-1,2-dihydroxy-ethyl)-non-3-enyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 85 percent / pyridine / 6 h / Ambient temperature
2: 90 percent / mercury(II) oxide, boron trifluoride etherate / tetrahydrofuran; H2O
3: 1.) NaNH2, HMPA / 1.) THF, -78 deg C, 2.) THF, RT, 8 h
4: 95 percent / trifluoroacetic acid / H2O / 0.5 h / 0 °C
With
pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; boron trifluoride diethyl etherate; sodium amide; trifluoroacetic acid; mercury(II) oxide;
In
tetrahydrofuran; water;
DOI:10.1080/00397919108021033
- Guidance literature:
-
Multi-step reaction with 5 steps
2: 90 percent / red HgO/BF3-Et2O / tetrahydrofuran; H2O
3: 71 percent / -78 °C
4: 98 percent / pyridine
5: 95 percent / aq. TFA / 0.5 h / -10 °C
With
boron trifluoride diethyl etherate; trifluoroacetic acid; mercury(II) oxide;
In
tetrahydrofuran; pyridine; water;
DOI:10.1016/S0040-4039(00)85345-9
