1-{[(2S)-1-ethoxy-2-methyl-3-(methylamino)-1,3-dioxopropan-2-yl](methyl)carbamolyl}-4-iodobenzene

Base Information

• Chemical Name: 1-{[(2S)-1-ethoxy-2-methyl-3-(methylamino)-1,3-dioxopropan-2-yl](methyl)carbamolyl}-4-iodobenzene
• CAS No.: 1344700-12-4
• Molecular Formula: C₁₅H₁₉IN₂O₄
• Molecular Weight: 418.231

Synonyms:1-{[(2S)-1-ethoxy-2-methyl-3-(methylamino)-1,3-dioxopropan-2-yl](methyl)carbamolyl}-4-iodobenzene

Chemical Property of 1-{[(2S)-1-ethoxy-2-methyl-3-(methylamino)-1,3-dioxopropan-2-yl](methyl)carbamolyl}-4-iodobenzene

Chemical Property:

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Technology Process of 1-{[(2S)-1-ethoxy-2-methyl-3-(methylamino)-1,3-dioxopropan-2-yl](methyl)carbamolyl}-4-iodobenzene

There total 2 articles about 1-{[(2S)-1-ethoxy-2-methyl-3-(methylamino)-1,3-dioxopropan-2-yl](methyl)carbamolyl}-4-iodobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-{[1-ethoxy-2-methyl-3-(methylamino)-1,3-dioxopropan-2-yl](methyl)carbamoyl}-4-iodobenzene (1344700-08-8) → 1-{[(2S)-1-ethoxy-2-methyl-3-(methylamino)-1,3-dioxopropan-2-yl](methyl)carbamolyl}-4-iodobenzene (1344700-12-4)

Guidance literature:

With carbon dioxide; In ethanol; acetonitrile;

Reference yield:

diethyl bromomethylmalonate (29263-94-3) → 1-{[(2S)-1-ethoxy-2-methyl-3-(methylamino)-1,3-dioxopropan-2-yl](methyl)carbamolyl}-4-iodobenzene (1344700-12-4)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrahydrofuran / 16 h / 20 °C / Cooling with ice

2: N-ethyl-N,N-diisopropylamine / chloroform / 0.67 h / 20 °C / Cooling with ice

3: carbon dioxide / ethanol; acetonitrile

With carbon dioxide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; chloroform; acetonitrile;

Reference yield: 62.0%

1-{[(2S)-1-ethoxy-2-methyl-3-(methylamino)-1,3-dioxopropan-2-yl](methyl)carbamolyl}-4-iodobenzene (1344700-12-4) → 1-{[(2S)-2-carboxy-1-(methylamino)-1-oxopropan-2-yl](methyl)carbamolyl}-4-iodobenzene (1344700-13-5)

Guidance literature:

With water; potassium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 0.5h;

upstream raw materials:

diethyl bromomethylmalonate

1-{[1-ethoxy-2-methyl-3-(methylamino)-1,3-dioxopropan-2-yl](methyl)carbamoyl}-4-iodobenzene

Downstream raw materials:

(2S)-2-(4-iodo-N-methylbenzamide)-N¹,2-dimethyl-N³-((tetrahydro-2H-pyran-2-yl)oxy)malonamide

(2S)-N-hydroxy-N',2-dimethyl-2-{methyl[(4-{[4-(1,4-oxazepan-4-ylmethyl)phenyl]ethynyl}phenyl)carbonyl]amino}propanediamide

(2S)-2-[{4-[(4-{[3-(2-fluoroethoxy)azetidin-1-yl]methyl}phenyl)ethynyl]benzoyl}(methyl)amino]-N,2-dimethyl-N'-(tetrahydro-2H-pyran-2-yloxy)propanediamide

(2S)-2-[(4-{[5-(methoxymethyl)furan-3-yl]ethynyl}benzoyl)(methyl)amino]-N,2-dimethyl-N'-(tetrahydro-2H-pyran-2-yloxy)propanediamide

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