Technology Process of 2-Amino-N-{4'-[3-(2-chloro-benzyl)-2-imino-2,3-dihydro-benzoimidazol-1-yl]-biphenyl-2-yl}-acetamide
There total 7 articles about 2-Amino-N-{4'-[3-(2-chloro-benzyl)-2-imino-2,3-dihydro-benzoimidazol-1-yl]-biphenyl-2-yl}-acetamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
O-(7-azabenzotriazole-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine;
In
1-methyl-pyrrolidin-2-one;
at 60 ℃;
for 5h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: triethylamine / 4 h / 150 °C / Microwave irradiaton
1.2: 0.25 h
2.1: tin(II) chloride dihdyrate / ethanol / 2.83 h / 70 °C
3.1: water; acetonitrile / 18 h / 20 °C
4.1: potassium iodide / acetonitrile / 0.17 h / 110 °C / Microwave irradiation
5.1: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,2-dimethoxyethane; water / 0.28 h / 150 °C / Microwave irradiation
6.1: O-(7-azabenzotriazole-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 5 h / 60 °C
With
O-(7-azabenzotriazole-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; tin(II) chloride dihdyrate; sodium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; potassium iodide;
tetrakis(triphenylphosphine) palladium(0);
In
1-methyl-pyrrolidin-2-one; 1,2-dimethoxyethane; ethanol; water; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: triethylamine / 4 h / 150 °C / Microwave irradiaton
1.2: 0.25 h
2.1: tin(II) chloride dihdyrate / ethanol / 2.83 h / 70 °C
3.1: water; acetonitrile / 18 h / 20 °C
4.1: potassium iodide / acetonitrile / 0.17 h / 110 °C / Microwave irradiation
5.1: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,2-dimethoxyethane; water / 0.28 h / 150 °C / Microwave irradiation
6.1: O-(7-azabenzotriazole-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 5 h / 60 °C
With
O-(7-azabenzotriazole-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; tin(II) chloride dihdyrate; sodium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; potassium iodide;
tetrakis(triphenylphosphine) palladium(0);
In
1-methyl-pyrrolidin-2-one; 1,2-dimethoxyethane; ethanol; water; acetonitrile;