3-AMINO-1-INDANONE

Base Information

• Chemical Name: 3-AMINO-1-INDANONE
• CAS No.: 117291-44-8
• Molecular Formula: C₉H₉NO
• Molecular Weight: 147.177
• Mol file: 117291-44-8.mol

Synonyms:3-AMINO-1-INDANONE

Chemical Property of 3-AMINO-1-INDANONE

Chemical Property:

• Boiling Point: 262.0±39.0 °C(Predicted)
• PKA: 7.01±0.20(Predicted)
• PSA: 43.09000
• Density: 1.200±0.06 g/cm3(Predicted)
• LogP: 1.97310

Purity/Quality:

98%min ^*data from raw suppliers

3-AMINO-1-INDANONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-AMINO-1-INDANONE

There total 5 articles about 3-AMINO-1-INDANONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

(+/-)-N-(1-oxo-1H-3-indanyl)-2,2,2trifluoroacetamide (117391-20-5) → 3-amino-1-indanone (117291-44-8)

Guidance literature:

With barium(II) hydroxide; In methanol; at 20 ℃; for 12h;

DOI:10.1021/jm301825t

Reference yield:

3-<(trifluoroacetyl)-amino>-3-phenylpropionic acid (21735-63-7) → 3-amino-1-indanone (117291-44-8)

Guidance literature:

Multi-step reaction with 3 steps

1: thionyl chloride / benzene / 0.5 h / Heating

2: 77 percent / aluminium chloride / CS₂ / 6 h / Heating

3: sodium hydroxide / H₂O / 0.5 h

With sodium hydroxide; aluminium trichloride; thionyl chloride; In carbon disulfide; water; benzene;

Reference yield:

3-Amino-3-phenylpropionic acid (3646-50-2) → 3-amino-1-indanone (117291-44-8)

Guidance literature:

Multi-step reaction with 4 steps

1: trifluoroacetic acid / 0.5 h / Heating

2: thionyl chloride / benzene / 0.5 h / Heating

3: 77 percent / aluminium chloride / CS₂ / 6 h / Heating

4: sodium hydroxide / H₂O / 0.5 h

With sodium hydroxide; aluminium trichloride; thionyl chloride; trifluoroacetic acid; In carbon disulfide; water; benzene;

upstream raw materials:

(+/-)-N-(1-oxo-1H-3-indanyl)-2,2,2trifluoroacetamide

3-<(trifluoroacetyl)-amino>-3-phenylpropionic acid

3-Amino-3-phenylpropionic acid

(+/-)-3-(2,2,2-trifluoroacetamido)-3-phenylpropanoyl chloride

Refernces

• 1、 Rault, Sylvain,Dallemagne, Patrick,Robba, Max. "Une synthese simple des premieres amino-3 indanones-1". . p. 1079 - 1083. Retrieved 2007/10/02.