3-phenyl-3-[(2,2,2-trifluoroacetyl)amino]propanoyl Chloride

Base Information

Chemical Name:3-phenyl-3-[(2,2,2-trifluoroacetyl)amino]propanoyl Chloride
CAS No.:117291-26-6
Molecular Formula:C11H9ClF3NO2
Molecular Weight:279.646
Hs Code.:
DSSTox Substance ID:DTXSID001196034

Synonyms:3-phenyl-3-[(2,2,2-trifluoroacetyl)amino]propanoyl Chloride;117291-26-6;CID 11818321;3-Phenyl-3-(2,2,2-trifluoroacetamido)propanoyl chloride;starbld0012601;SCHEMBL8062913;QJUXCDJANGCSQU-UHFFFAOYSA-N;DTXSID001196034;beta-[(2,2,2-Trifluoroacetyl)amino]benzenepropanoyl chloride

Suppliers and Price of 3-phenyl-3-[(2,2,2-trifluoroacetyl)amino]propanoyl Chloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 3-phenyl-3-[(2,2,2-trifluoroacetyl)amino]propanoyl Chloride

Chemical Property:

XLogP3:2.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:279.0273907
Heavy Atom Count:18
Complexity:314

Purity/Quality:: 99.90% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)C(CC(=O)Cl)NC(=O)C(F)(F)F

Technology Process of 3-phenyl-3-[(2,2,2-trifluoroacetyl)amino]propanoyl Chloride

There total 5 articles about 3-phenyl-3-[(2,2,2-trifluoroacetyl)amino]propanoyl Chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 21735-63-7
3-<(trifluoroacetyl)-amino>-3-phenylpropionic acid

: 117291-26-6
(+/-)-3-(2,2,2-trifluoroacetamido)-3-phenylpropanoyl chloride

Guidance literature:: With thionyl chloride; at 82 ℃; for 24h; Inert atmosphere;
DOI:10.1016/j.bmc.2013.01.035

Reference yield:

: 3646-50-2
3-Amino-3-phenylpropionic acid

: 117291-26-6
(+/-)-3-(2,2,2-trifluoroacetamido)-3-phenylpropanoyl chloride

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid

2: oxalyl chloride / CH₂Cl₂

With oxalyl dichloride; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/S0040-4039(01)01991-8

Reference yield:

: 100-52-7
benzaldehyde

: 117291-26-6
(+/-)-3-(2,2,2-trifluoroacetamido)-3-phenylpropanoyl chloride

Guidance literature:: Multi-step reaction with 3 steps

1: 65 percent / AcONH₄ / ethanol / 6 h / Heating

2: 85 percent / 0.5 h / Ambient temperature

3: 95 percent / SOCl₂ / 0.5 h / Heating

With thionyl chloride; ammonium acetate; In ethanol;
DOI:10.1016/0223-5234(92)90029-Z