ethyl 2-benzamido-4-(trifluoromethyl)oxazole-5-carboxylate

Base Information

• Chemical Name: ethyl 2-benzamido-4-(trifluoromethyl)oxazole-5-carboxylate
• CAS No.: 1228004-41-8
• Molecular Formula: C₁₄H₁₁F₃N₂O₄
• Molecular Weight: 328.248
• Mol file: 1228004-41-8.mol

Synonyms:ethyl 2-benzamido-4-(trifluoromethyl)oxazole-5-carboxylate

Chemical Property of ethyl 2-benzamido-4-(trifluoromethyl)oxazole-5-carboxylate

Chemical Property:

Purity/Quality:

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Technology Process of ethyl 2-benzamido-4-(trifluoromethyl)oxazole-5-carboxylate

There total 1 articles about ethyl 2-benzamido-4-(trifluoromethyl)oxazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

benzoyl chloride (98-88-4) + ethyl 2-amino-4-(trifluoromethyl)oxazole-5-carboxylate (135026-17-4) → ethyl 2-benzamido-4-(trifluoromethyl)oxazole-5-carboxylate (1228004-41-8)

Guidance literature:

With triethylamine; dmap; In tetrahydrofuran; at 20 ℃; for 16h; Inert atmosphere;

Reference yield: 99.0%

ethyl 2-benzamido-4-(trifluoromethyl)oxazole-5-carboxylate (1228004-41-8) → 2-benzamido-4-(trifluoromethyl)oxazole-5-carboxylic acid (1228004-40-7)

Guidance literature:

ethyl 2-benzamido-4-(trifluoromethyl)oxazole-5-carboxylate; With water; sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 3h;

With hydrogenchloride; In water; pH=~ 1;

upstream raw materials:

benzoyl chloride

ethyl 2-amino-4-(trifluoromethyl)oxazole-5-carboxylate

Downstream raw materials:

2-benzamido-4-(trifluoromethyl)oxazole-5-carboxylic acid