Technology Process of 2H-1-Benzopyran-7-ol,3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidinyl)ethoxy]phenyl]-, (2R)-
There total 6 articles about 2H-1-Benzopyran-7-ol,3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidinyl)ethoxy]phenyl]-, (2R)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 69 percent / TsOH / 2.5 h / 0 °C
2: 1.) piperidine, 2.) Cs2CO3, H2O / 1.) benzene, reflux, 60 h, 2.) acetone, reflux, 19 h
3: tetrahydrofuran / 3 h / -78 - 20 °C
4: aq. AcOH / 0.5 h / 90 °C
With
piperidine; water; caesium carbonate; toluene-4-sulfonic acid; acetic acid;
In
tetrahydrofuran;
DOI:10.1021/jm970095o
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 70 percent / BF3*Et2O / 1 h / 100 °C
2: 69 percent / TsOH / 2.5 h / 0 °C
3: 1.) piperidine, 2.) Cs2CO3, H2O / 1.) benzene, reflux, 60 h, 2.) acetone, reflux, 19 h
4: tetrahydrofuran / 3 h / -78 - 20 °C
5: aq. AcOH / 0.5 h / 90 °C
With
piperidine; boron trifluoride diethyl etherate; water; caesium carbonate; toluene-4-sulfonic acid; acetic acid;
In
tetrahydrofuran;
DOI:10.1021/jm970095o
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) piperidine, 2.) Cs2CO3, H2O / 1.) benzene, reflux, 60 h, 2.) acetone, reflux, 19 h
2: tetrahydrofuran / 3 h / -78 - 20 °C
3: aq. AcOH / 0.5 h / 90 °C
With
piperidine; water; caesium carbonate; acetic acid;
In
tetrahydrofuran;
DOI:10.1021/jm970095o
