7-(benzyloxy)-3-(hydroxymethyl)-2-(2-methylpropyl)-4-phenylisoquinolin-1(2H)-one

Base Information

Chemical Name:7-(benzyloxy)-3-(hydroxymethyl)-2-(2-methylpropyl)-4-phenylisoquinolin-1(2H)-one
CAS No.:447425-64-1
Molecular Formula:C₂₇H₂₇NO₃
Molecular Weight:413.516
Hs Code.:

Synonyms:7-(benzyloxy)-3-(hydroxymethyl)-2-(2-methylpropyl)-4-phenylisoquinolin-1(2H)-one

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Chemical Property of 7-(benzyloxy)-3-(hydroxymethyl)-2-(2-methylpropyl)-4-phenylisoquinolin-1(2H)-one

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Technology Process of 7-(benzyloxy)-3-(hydroxymethyl)-2-(2-methylpropyl)-4-phenylisoquinolin-1(2H)-one

There total 6 articles about 7-(benzyloxy)-3-(hydroxymethyl)-2-(2-methylpropyl)-4-phenylisoquinolin-1(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₇H₂₄ClNO₃

: 447425-64-1
7-(benzyloxy)-3-(hydroxymethyl)-2-(2-methylpropyl)-4-phenylisoquinolin-1(2H)-one

Guidance literature:: C₂₇H₂₄ClNO₃; With sodium tetrahydroborate; In tetrahydrofuran; 1,2-dimethoxyethane; at 0 ℃; for 1h;

With hydrogenchloride; In tetrahydrofuran; 1,2-dimethoxyethane; water;
DOI:10.1016/j.bmc.2011.06.059

Reference yield:

: 447425-62-9
C₂₉H₂₉NO₄

: 447425-64-1
7-(benzyloxy)-3-(hydroxymethyl)-2-(2-methylpropyl)-4-phenylisoquinolin-1(2H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / tetrahydrofuran; ethanol; water / 3 h / Reflux

2: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran / 1 h / 20 °C

3: sodium tetrahydroborate / tetrahydrofuran; 1,2-dimethoxyethane / 1 h / 0 °C

With sodium tetrahydroborate; oxalyl dichloride; N,N-dimethyl-formamide; sodium hydroxide; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; water;
DOI:10.1016/j.bmc.2011.06.059

Reference yield:

: 447424-26-2
ethyl 7-(benzyloxy)-4-hydroxy-2-(2-methylpropyl)-1-oxo-1,2-dihydroisoquinoline-3-carboxylate

: 447425-64-1
7-(benzyloxy)-3-(hydroxymethyl)-2-(2-methylpropyl)-4-phenylisoquinolin-1(2H)-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

1.2: 6 h / 20 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / methanol; water; toluene / 10 h / Inert atmosphere; Reflux

3.1: sodium hydroxide / tetrahydrofuran; ethanol; water / 3 h / Reflux

4.1: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran / 1 h / 20 °C

5.1: sodium tetrahydroborate / tetrahydrofuran; 1,2-dimethoxyethane / 1 h / 0 °C

With sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; oxalyl dichloride; sodium hydride; sodium carbonate; N,N-dimethyl-formamide; sodium hydroxide; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide; toluene; 2.1: Suzuki coupling;
DOI:10.1016/j.bmc.2011.06.059