ethyl 7-(benzyloxy)-4-hydroxy-2-(2-methylpropyl)-1-oxo-1,2-dihydroisoquinoline-3-carboxylate

Base Information

Chemical Name:ethyl 7-(benzyloxy)-4-hydroxy-2-(2-methylpropyl)-1-oxo-1,2-dihydroisoquinoline-3-carboxylate
CAS No.:447424-26-2
Molecular Formula:C₂₃H₂₅NO₅
Molecular Weight:395.455
Hs Code.:

Synonyms:ethyl 7-(benzyloxy)-4-hydroxy-2-(2-methylpropyl)-1-oxo-1,2-dihydroisoquinoline-3-carboxylate

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Chemical Property of ethyl 7-(benzyloxy)-4-hydroxy-2-(2-methylpropyl)-1-oxo-1,2-dihydroisoquinoline-3-carboxylate

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Technology Process of ethyl 7-(benzyloxy)-4-hydroxy-2-(2-methylpropyl)-1-oxo-1,2-dihydroisoquinoline-3-carboxylate

There total 2 articles about ethyl 7-(benzyloxy)-4-hydroxy-2-(2-methylpropyl)-1-oxo-1,2-dihydroisoquinoline-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.6%

: 5840-65-3
5-(benzyloxy)-2-benzofuran-1,3-dione

: 3182-87-4
N-isobutylglycine ethyl ester

: 75-03-6
ethyl iodide

: 447424-26-2
ethyl 7-(benzyloxy)-4-hydroxy-2-(2-methylpropyl)-1-oxo-1,2-dihydroisoquinoline-3-carboxylate

Guidance literature:: With sodium ethanolate; potassium carbonate; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;

Reference yield: 13.0%

: 5840-65-3
5-(benzyloxy)-2-benzofuran-1,3-dione

: 3182-87-4
N-isobutylglycine ethyl ester

: 75-03-6
ethyl iodide

: 447424-27-3
ethyl 6-(benzyloxy)-4-hydroxy-2-(2-methylpropyl)-1-oxo-1,2-dihydroisoquinoline-3-carboxylate

: 447424-26-2
ethyl 7-(benzyloxy)-4-hydroxy-2-(2-methylpropyl)-1-oxo-1,2-dihydroisoquinoline-3-carboxylate

Guidance literature:: 5-(benzyloxy)-2-benzofuran-1,3-dione; N-isobutylglycine ethyl ester; In tetrahydrofuran; at 20 ℃; for 1h;

ethyl iodide; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 3h; Further stages;
DOI:10.1016/j.bmc.2011.06.059

Reference yield: 91.0%

: 37595-74-7
N,N-phenylbistrifluoromethane-sulfonimide

: 447424-26-2
ethyl 7-(benzyloxy)-4-hydroxy-2-(2-methylpropyl)-1-oxo-1,2-dihydroisoquinoline-3-carboxylate

: 447425-61-8
ethyl 7-(benzyloxy)-2-(2-methylpropyl)-1-oxo-4-{[(trifluoromethyl)sulfonyl]oxy}-1,2-dihydroisoquinoline-3-carboxylate

Guidance literature:: ethyl 7-(benzyloxy)-4-hydroxy-2-(2-methylpropyl)-1-oxo-1,2-dihydroisoquinoline-3-carboxylate; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h;

N,N-phenylbistrifluoromethane-sulfonimide; In N,N-dimethyl-formamide; at 20 ℃; for 6h;
DOI:10.1016/j.bmc.2011.06.059