N-(4-(4-[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]piperazin-1-yl)phenyl)palmitamide

Base Information

Chemical Name:N-(4-(4-[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]piperazin-1-yl)phenyl)palmitamide
CAS No.:1312759-96-8
Molecular Formula:C₃₇H₅₄F₂N₆O₂
Molecular Weight:652.872
Hs Code.:

Synonyms:N-(4-(4-[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]piperazin-1-yl)phenyl)palmitamide

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Chemical Property of N-(4-(4-[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]piperazin-1-yl)phenyl)palmitamide

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Technology Process of N-(4-(4-[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]piperazin-1-yl)phenyl)palmitamide

There total 4 articles about N-(4-(4-[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]piperazin-1-yl)phenyl)palmitamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 376646-71-8
1-[4-(4-amino-phenyl)-piperazin-1-yl]-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)-propan-2-ol

: 57-10-3
1-hexadecylcarboxylic acid

: 1312759-96-8
N-(4-(4-[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]piperazin-1-yl)phenyl)palmitamide

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20 ℃;
DOI:10.1016/j.ejmech.2011.02.042

Reference yield:

: 1-(1H-1,2,4-triazol-1-yl)-2-(2,4-difluorophenyl)-3-[4-(4-nitrophenyl)piperazin-1-yl]propan-2-ol

: 1312759-96-8
N-(4-(4-[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]piperazin-1-yl)phenyl)palmitamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrazine hydrate / ethanol / 3.5 h / 80 °C

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C

With dmap; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; dichloromethane;
DOI:10.1016/j.ejmech.2011.02.042

Reference yield:

: 86386-77-8
1-[2-(2,4-difluorophenyl)-2,3-epoxypropyl]-1H-1,2,4-triazole methanesulfonate

: 1312759-96-8
N-(4-(4-[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]piperazin-1-yl)phenyl)palmitamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / ethanol / 5 h / 80 °C

2: hydrazine hydrate / ethanol / 3.5 h / 80 °C

3: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C

With dmap; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In ethanol; dichloromethane;
DOI:10.1016/j.ejmech.2011.02.042