2-((2R,3R)-4-(anthracen-9-yl)-3-(tert-butyl)-2,3-dihydrobenzo[d][1,3]oxaphosphol-2-yl)pyridine

Base Information

• Chemical Name: 2-((2R,3R)-4-(anthracen-9-yl)-3-(tert-butyl)-2,3-dihydrobenzo[d][1,3]oxaphosphol-2-yl)pyridine
• CAS No.: 1542796-14-4
• Molecular Formula: C₃₀H₂₆NOP
• Molecular Weight: 447.516
• Mol file: 1542796-14-4.mol

Synonyms:2-((2R,3R)-4-(anthracen-9-yl)-3-(tert-butyl)-2,3-dihydrobenzo[d][1,3]oxaphosphol-2-yl)pyridine

Chemical Property of 2-((2R,3R)-4-(anthracen-9-yl)-3-(tert-butyl)-2,3-dihydrobenzo[d][1,3]oxaphosphol-2-yl)pyridine

Chemical Property:

• Boiling Point: 621.8±55.0 °C(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

2-((2R,3R)-4-(Anthracen-9-yl)-3-(tert-butyl)-2,3-dihydrobenzo[d][1,3]oxaphosphol-2-yl)pyridine, 97% (>99% ee) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-((2R,3R)-4-(anthracen-9-yl)-3-(tert-butyl)-2,3-dihydrobenzo[d][1,3]oxaphosphol-2-yl)pyridine

There total 4 articles about 2-((2R,3R)-4-(anthracen-9-yl)-3-(tert-butyl)-2,3-dihydrobenzo[d][1,3]oxaphosphol-2-yl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

(2R,3S)-4-(anthracen-9-yl)-3-(tert-butyl)-2-(pyridin-2-yl)-2H-benzo[d][1,3]oxaphosphole-3-oxide (1542796-01-9) → 2-((2R,3R)-4-(anthracen-9-yl)-3-(tert-butyl)-2,3-dihydrobenzo[d][1,3]oxaphosphol-2-yl)pyridine (1542796-14-4,2565792-34-7)

Guidance literature:

With titanium(IV) isopropylate; In 1,1,1-trichloroethane; at 65 ℃; for 14h; Inert atmosphere; Schlenk technique;

DOI:10.1021/jo4024864

Reference yield: 87.0%

→ 2-((2R,3R)-4-(anthracen-9-yl)-3-(tert-butyl)-2,3-dihydrobenzo[d][1,3]oxaphosphol-2-yl)pyridine (1542796-14-4,2565792-34-7)

Guidance literature:

With titanium(IV) isopropylate; In tetrahydrofuran; at 65 ℃; for 14h; Inert atmosphere; Schlenk technique;

Reference yield:

2-(phenylsulfonyl)pyridine (24244-60-8) → 2-((2R,3R)-4-(anthracen-9-yl)-3-(tert-butyl)-2,3-dihydrobenzo[d][1,3]oxaphosphol-2-yl)pyridine (1542796-14-4,2565792-34-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; ethylbenzene / 1 h / -78 - -70 °C / Inert atmosphere

1.2: 2 h / -78 - 20 °C

2.1: titanium(IV) isopropylate / 1,1,1-trichloroethane / 14 h / 65 °C / Inert atmosphere; Schlenk technique

With titanium(IV) isopropylate; lithium diisopropyl amide; In tetrahydrofuran; 1,1,1-trichloroethane; ethylbenzene;

DOI:10.1021/jo4024864

upstream raw materials:

(2R,3S)-4-(anthracen-9-yl)-3-(tert-butyl)-2-(pyridin-2-yl)-2H-benzo[d][1,3]oxaphosphole-3-oxide

2-chloropyridine

2-(phenylsulfonyl)pyridine

Downstream raw materials:

{2-((2R,3R)-4-(anthracen-9-yl)-3-(tert-butyl)-2,3-dihydrobenzo[d][1,3]oxaphosphol-2-yl)pyridine}(η4-1,5-cyclooctadiene)iridium(I) tetrakis[3,5-bis(trifluoromethyl)phenyl]borate