N-[3-amino-4-(1,3,5-trimethylpyrazol-4-yl)phenyl](4-chlorophenyl)carboxamide

Base Information

Chemical Name:N-[3-amino-4-(1,3,5-trimethylpyrazol-4-yl)phenyl](4-chlorophenyl)carboxamide
CAS No.:1346665-66-4
Molecular Formula:C₁₉H₁₉ClN₄O
Molecular Weight:354.839
Hs Code.:

Synonyms:N-[3-amino-4-(1,3,5-trimethylpyrazol-4-yl)phenyl](4-chlorophenyl)carboxamide

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Chemical Property of N-[3-amino-4-(1,3,5-trimethylpyrazol-4-yl)phenyl](4-chlorophenyl)carboxamide

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Technology Process of N-[3-amino-4-(1,3,5-trimethylpyrazol-4-yl)phenyl](4-chlorophenyl)carboxamide

There total 5 articles about N-[3-amino-4-(1,3,5-trimethylpyrazol-4-yl)phenyl](4-chlorophenyl)carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 1346665-65-3
4-(1,3,5-trimethylpyrazol-4-yl)benzene-1,3-diamine

: 122-01-0
4-chloro-benzoyl chloride

: 1346665-66-4
N-[3-amino-4-(1,3,5-trimethylpyrazol-4-yl)phenyl](4-chlorophenyl)carboxamide

Guidance literature:: With dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 584-48-5
2,4-dinitrobromobenzene

: 1346665-66-4
N-[3-amino-4-(1,3,5-trimethylpyrazol-4-yl)phenyl](4-chlorophenyl)carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; ethanol; water / 0.5 h / 110 °C / Inert atmosphere; microwave irradiation

2: hydrogen / palladium 10% on activated carbon / methanol / 20 °C

3: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C

With dmap; hydrogen; sodium carbonate; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; water;

Reference yield:

: 74-11-3
para-chlorobenzoic acid

: 1346665-66-4
N-[3-amino-4-(1,3,5-trimethylpyrazol-4-yl)phenyl](4-chlorophenyl)carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 2 h / 0 - 20 °C

2: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C

With dmap; oxalyl dichloride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In dichloromethane;