2-((1S, 4aS, 8aS)-5,5,8a-trimethyl-2-methylenedecahydronaphthalen-1-yl)acetic acid

Base Information

• Chemical Name: 2-((1S, 4aS, 8aS)-5,5,8a-trimethyl-2-methylenedecahydronaphthalen-1-yl)acetic acid
• CAS No.: 29065-24-5
• Molecular Formula: C₁₆H₂₆O₂
• Molecular Weight: 250.381
• Mol file: 29065-24-5.mol

Synonyms:2-((1S, 4aS, 8aS)-5,5,8a-trimethyl-2-methylenedecahydronaphthalen-1-yl)acetic acid

Chemical Property of 2-((1S, 4aS, 8aS)-5,5,8a-trimethyl-2-methylenedecahydronaphthalen-1-yl)acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-((1S, 4aS, 8aS)-5,5,8a-trimethyl-2-methylenedecahydronaphthalen-1-yl)acetic acid

There total 1 articles about 2-((1S, 4aS, 8aS)-5,5,8a-trimethyl-2-methylenedecahydronaphthalen-1-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(+)-manool (596-85-0,29461-42-5,41357-91-9,106631-38-3,1438-62-6) → 2-((1S, 4aS, 8aS)-5,5,8a-trimethyl-2-methylenedecahydronaphthalen-1-yl)acetic acid (29065-24-5)

Guidance literature:

Multi-step reaction with 2 steps

1: KMnO₄; MgSO₄ / acetone / 20 °C

2: 66 percent / oxygen / 1,2-dimethoxy-ethane / 4 h / 20 °C

With potassium permanganate; oxygen; magnesium sulfate; In 1,2-dimethoxyethane; acetone;

DOI:10.1080/00397910500377172

Reference yield: 53.0%

pyrimidin-4-amine (163133-86-6,163133-87-7,176772-96-6,176773-06-1,176773-07-2,176799-58-9,591-54-8) + 2-((1S, 4aS, 8aS)-5,5,8a-trimethyl-2-methylenedecahydronaphthalen-1-yl)acetic acid (29065-24-5) + dicyclohexyl-carbodiimide (538-75-0) → N-Δ8,13-bicyclohomofarnezenoyl-N,N′-dicyclohexylurea (1424348-25-3) + Δ8,13-bicyclohomofarnezenic acid N-(pyrimidin-4-yl)amide (1424348-20-8) + 1,3-Dicyclohexylurea (2387-23-7)

Guidance literature:

With dmap; In dichloromethane; at 20 ℃; for 10h;

DOI:10.1055/s-0032-1318253

Reference yield: 53.0%

pyrimidin-4-amine (163133-86-6,163133-87-7,176772-96-6,176773-06-1,176773-07-2,176799-58-9,591-54-8) + 2-((1S, 4aS, 8aS)-5,5,8a-trimethyl-2-methylenedecahydronaphthalen-1-yl)acetic acid (29065-24-5) → N-Δ8,13-bicyclohomofarnezenoyl-N,N′-dicyclohexylurea (1424348-25-3) + Δ8,13-bicyclohomofarnezenic acid N-(pyrimidin-4-yl)amide (1424348-20-8)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; for 15h; Reflux;

DOI:10.1007/s00044-013-0720-3

upstream raw materials:

(+)-manool

Downstream raw materials:

α-onoceradiene

(-)-ent-zonarol

(-)-ent-zonarol di-THP ether

[2,5-bis-(tetrahydro-pyran-2-yloxy)-phenyl]-(5,5,8a-trimethyl-2-methylene-decahydro-naphthalen-1-yl)-methanol